Publication Name	World Journal of Biological Chemistry
Manuscript ID	112221
Country	Lebanon

Category	Cell Biology
Manuscript Type	Systematic Reviews
Article Title	Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies
Manuscript Source	Unsolicited Manuscript
All Author List	Razan Abdulaal, Imad Afara, Ali Harajli, Ehab Al Mashtoub, Alaa Tarchichi, Karim Hassan, Ali Afara, Jana Abou Fakher, Sethrida Salhab, Issam Fassih and Mohamad Tlais
Funding Agency and Grant Number
Corresponding Author	Mohamad Tlais, Department of Cardiology, University of Balamand, Dekweneh, Beirut 1100, Beyrouth, Lebanon. mmtlaiss22@gmail.com
Key Words	Gut microbiome; Chemotherapy-induced cardiotoxicity; Short-chain fatty acids; Trimethylamine-N-oxide; Gut-heart axis; Microbiome-targeted therapies
Core Tip	This systematic review highlights the emerging role of the gut microbiome in chemotherapy-induced cardiotoxicity, focusing on how dysbiosis disrupts microbial metabolite balance, particularly short-chain fatty acids and trimethylamine-N-oxide, to drive inflammation, oxidative stress, and cardiac damage. The review synthesizes mechanistic insights and evaluates microbiome-targeted interventions such as probiotics, prebiotics, and fecal microbiota transplantation. It emphasizes the gut-heart axis as a novel therapeutic target in cardio-oncology and underscores the need for standardized clinical trials to translate these findings into personalized medicine.
Citation	Abdulaal R, Afara I, Harajli A, Al Mashtoub E, Tarchichi A, Hassan K, Afara A, Abou Fakher J, Salhab S, Fassih I, Tlais M. Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies. World J Biol Chem 2025; In press

Received	2025-07-21 01:15
Peer-Review Started	2025-07-21 01:16
To Make the First Decision
Return for Revision	2025-07-30 07:55
Revised	2025-08-03 22:09
Second Decision	2025-10-20 02:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-21 01:57
Articles in Press	2025-10-21 01:57
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Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8454 (online)
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