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Articles in Press
11/27/2025 6:24:15 AM | Browse: 1 | Download: 0
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
Knockdown of 5-methylcytosine RNA methyltransferase NOP2/sun RNA methyltransferase 5 in hepatocellular carcinoma cells affects their biological functions
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Na Liu, Jin Liu, Yin-Ling Wang, Li Zhu and Chuan-Wu Zhu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82172252 |
| Suzhou Major Disease Multicenter Clinical Research Project |
No. DZXYJ202310 |
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| Corresponding Author |
Chuan-Wu Zhu, Chief Physician, Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, No. 10 Guangqian Road, Xiangcheng District, Suzhou 215131, Jiangsu Province, China. zhuchw@126.com |
| Key Words |
RNA 5-methylcytosine; Methyltransferase; NOP2/sun RNA methyltransferase 5; Hepatocellular carcinoma; Biological behavior |
| Core Tip |
Epigenetic modifications are dynamic, reversible, and heritable chemical changes to biomolecules that occur without altering the sequence of nuclear DNA. Among these, the RNA modification 5-methylcytosine has garnered increasing attention. However, the roles of RNA modification 5-methylcytosine modifications and their modifying enzymes in gene regulation and chromatin organization remain largely unclear. While previous studies have reported the involvement of NOP2/sun RNA methyltransferase 5 in human cancers, its comprehensive role in hepatocellular carcinoma remains unexplored. Therefore, this study evaluates the effects of NOP2/sun RNA methyltransferase 5 on hepatocellular carcinoma cell growth, migration, and invasion at the cellular level. |
| Citation |
Liu N, Liu J, Wang YL, Zhu L, Zhu CW. Knockdown of 5-methylcytosine RNA methyltransferase NOP2/sun RNA methyltransferase 5 in hepatocellular carcinoma cells affects their biological functions. World J Gastrointest Surg 2025; In press |
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Received |
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2025-09-02 08:51 |
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Peer-Review Started |
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2025-09-02 08:51 |
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To Make the First Decision |
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Return for Revision |
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2025-09-22 09:05 |
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Revised |
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2025-10-16 13:38 |
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Second Decision |
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2025-11-27 02:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-11-27 06:24 |
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Articles in Press |
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2025-11-27 06:24 |
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Publication Fee Transferred |
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2025-10-22 06:00 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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