Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	112256
Country	China

Category	Nutrition & Dietetics
Manuscript Type	Meta-Analysis
Article Title	Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Yong Huang, Xiu-Zhi Yang, Song-Han Qin, Tao Zhang, Ming Xie and Ji-Wei Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81960105 Medical Research Union Fund for High-quality Health Development of Guizhou Province 2024GZYXKYJJXM0155
Corresponding Author	Ji-Wei Wang, Department of General Surgery, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, No. 140 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. jiwei_wang@zmu.edu.cn
Key Words	Colorectal cancer; Immune function; Inflammation levels; Length of stay; Nitrogen balance; Nutritional status; Postoperative complications
Core Tip	Our study found that glutamine (Gln) supplementation could not only effectively improve the postoperative nutritional status, reduce the incidence of postoperative complications and shorten the length of hospital stay, but also, importantly, maintain nitrogen balance, enhance immune function and reduce inflammation levels of colorectal cancer (CRC) patients, without the interference of comorbidities and other immune nutrients. On the basis of previous studies, this further confirmed that perioperative application of Gln can bring positive prognosis to CRC patients, and provided an evidence-based basis for the widespread clinical application of Gln.
Citation	Huang Y, Yang XZ, Qin SH, Zhang T, Xie M, Wang JW. Effect of perioperative glutamine-enriched nutritional support on patients with colorectal cancer: A systematic review and meta-analysis. World J Gastrointest Surg 2025; In press

Received	2025-07-22 08:17
Peer-Review Started	2025-07-22 08:33
To Make the First Decision
Return for Revision	2025-08-19 07:17
Revised	2025-08-28 10:49
Second Decision	2025-10-20 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 08:36
Articles in Press	2025-10-20 08:36
Publication Fee Transferred	2025-08-30 20:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com