Publication Name	World Journal of Critical Care Medicine
Manuscript ID	112265
Country	Russia

Category	Pediatrics
Manuscript Type	Retrospective Cohort Study
Article Title	Death in patients with immune-mediated inflammatory diseases in the intensive care unit: First week data
Manuscript Source	Invited Manuscript
All Author List	Ilia S Avrusin, Natalia N Abramova, Liudmila A Firsova, Yury S Aleksandrovich, Dmitry O Ivanov and Mikhail M Kostik
Funding Agency and Grant Number
Corresponding Author	Mikhail M Kostik, MD, PhD, Professor, Hospital Pediatrics, Saint Petersburg State Pediatric Medical University, Lytovskaya 2, Saint Petersburg 194100, Sankt-Peterburg, Russia. kost-mikhail@yandex.ru
Key Words	Intensive care unit; Systemic inflammation; Systemic rheumatic diseases; Sepsis; Multisystem inflammatory syndrome associated with coronavirus disease 2019 in children; Children
Core Tip	Systemic immune-mediated inflammatory diseases can be severe in both course and complications, quite often requiring intensive care unit admission and, in some cases, leading to death. For such patients, careful observation and dynamic monitoring of their condition, along with risk assessment, is critical. The risk factors for a lethal outcome during the first week of intensive care unit stay included signs of hemophagocytosis, progressive decline in the Glasgow Coma Scale, increasing Sequential Organ Failure Assessment scores, and persistent high C-reactive protein levels. Monitoring of these parameters may help to timely identify the patients at high risk of lethal outcome, allowing for the prompt prescription of appropriate treatment.
Citation	Avrusin IS, Abramova NN, Firsova LA, Aleksandrovich YS, Ivanov DO, Kostik MM. Death in patients with immune-mediated inflammatory diseases in the intensive care unit: First week data. World J Crit Care Med 2025; In press

Received	2025-07-23 04:46
Peer-Review Started	2025-07-23 04:46
To Make the First Decision
Return for Revision	2025-08-27 07:50
Revised	2025-09-10 04:12
Second Decision	2025-11-27 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-27 08:35
Articles in Press	2025-11-27 08:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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