Publication Name	World Journal of Stem Cells
Manuscript ID	112278
Country	China

Category	Pathology
Manuscript Type	Basic Study
Article Title	Hypoxia facilitates triple-negative breast cancer stem cells enrichment and stemness maintenance through oxidized ataxia telangiectasia mutated-induced one-carbon metabolism
Manuscript Source	Unsolicited Manuscript
All Author List	Dan Yang, Yu-Lian Ou, Shu-Hui Wang, Hong-Jun Jin, Su-Hua Chen, Ran Han and Hua Zhang
Funding Agency and Grant Number
Corresponding Author	Ran Han, Outpatient Department, Guizhou Provincial People’s Hospital, No. 83 Zhongshan East Road, Guiyang 550002, Guizhou Province, China. hanran105@sina.com
Key Words	Hypoxia; Oxidized ataxia telangiectasia mutated; Cancer stem cells; Triple-negative breast cancer; One-carbon metabolism; Methylenetetrahydrofolate dehydrogenase 2; Serine hydroxymethyltransferase 2
Core Tip	This study demonstrates that hypoxia activates oxidized ataxia telangiectasia mutated kinase, which plays a pivotal role in enhancing the stemness of triple-negative breast cancer stem cells. Through c-Myc-mediated transcriptional regulation, hypoxia promotes one-carbon metabolism and significantly upregulates key metabolic enzymes, including methylenetetrahydrofolate dehydrogenase 2 and serine hydroxymethyltransferase 2. These metabolic adaptations support redox balance and self-renewal capacity, highlighting a potential therapeutic axis targeting oxidized ataxia telangiectasia mutated-driven metabolic reprogramming in triple-negative breast cancer.
Citation	Yang D, Ou YL, Wang SH, Jin HJ, Chen SH, Han R, Zhang H. Hypoxia facilitates triple-negative breast cancer stem cells enrichment and stemness maintenance through oxidized ataxia telangiectasia mutated-induced one-carbon metabolism. World J Stem Cells 2025; In press

Received	2025-07-23 05:30
Peer-Review Started	2025-07-23 05:31
First Decision by Editorial Office Director	2025-08-14 04:55
Return for Revision	2025-08-14 04:55
Revised	2025-09-09 02:26
Publication Fee Transferred	2025-09-17 01:39
Second Decision by Editor	2025-11-21 10:23
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-02 07:56
Articles in Press	2025-12-02 07:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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