Publication Name	World Journal of Nephrology
Manuscript ID	112302
Country	Pakistan

Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Sodium-glucose cotransporter-2 inhibitors beyond glycemic control: Their role in acute kidney injury recovery
Manuscript Source	Invited Manuscript
All Author List	Muhammad Umar Ahsan, Sana Iftikhar, Umme E Ambreen, Fahad Nazir, Matia Fawad, Khadija Nasir and Ume Roman Leghari
Funding Agency and Grant Number
Corresponding Author	Muhammad Umar Ahsan, Researcher, Department of Medicine, D.G.Khan Medical College, Dera Ghazi Khan 32200, Punjab, Pakistan. umarahsan219@gmail.com
Key Words	Sodium-glucose cotransporter-2 inhibitors; Acute kidney injury; Renal protection; Ischemia-reperfusion; Oxidative stress; Tubuloglomerular feedback
Core Tip	Sodium-glucose cotransporter-2 (SGLT2) inhibitors, traditionally used for glycemic control in type 2 diabetes, show emerging promise in acute kidney injury (AKI) recovery through mechanisms such as oxidative stress reduction, anti-inflammatory effects, improved mitochondrial function, and hemodynamic modulation. Although encouraging data from preclinical and observational studies exist, robust randomized controlled trials are lacking. This mini-review synthesizes current evidence, evaluates its quality, summarizes ongoing clinical trials, and highlights priority areas for future research to guide the safe and effective integration of SGLT2 inhibitors into AKI management.
Citation	Ahsan MU, Iftikhar S, Ambreen UE, Nazir F, Fawad M, Nasir K, Leghari UR. Sodium-glucose cotransporter-2 inhibitors beyond glycemic control: Their role in acute kidney injury recovery. World J Nephrol 2025; In press

Received	2025-07-23 01:55
Peer-Review Started	2025-07-23 01:56
First Decision by Editorial Office Director	2025-08-01 09:32
Return for Revision	2025-08-01 09:32
Revised	2025-08-15 20:58
Publication Fee Transferred
Second Decision by Editor	2025-12-08 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-08 07:11
Articles in Press	2025-12-08 07:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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