Publication Name	World Journal of Cardiology
Manuscript ID	112321
Country	Australia

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Retrospective Cohort Study
Article Title	Fixed vs weight-based heparin dosing in stable patients undergoing diagnostic coronary physiology studies
Manuscript Source	Invited Manuscript
All Author List	Kristoffer Ken Ralota, Deniz Tuncer, Nay Min Htun, Rohit Samuel, Vivek Gupta, Robert Lew and Jamie Layland
Funding Agency and Grant Number
Corresponding Author	Jamie Layland, Consultant, FRACP, MD, MRCP, PhD, Professor, Senior Researcher, Department of Medicine, Peninsula Health, Monash University, 2 Hastings Road, Frankston, Melbourne, Frankston 3199, Victoria, Australia. jlayland@phcn.vic.gov.au
Key Words	Unfractionated heparin; Coronary physiology; Fractional flow reserve; Microvascular function; Anticoagulation; Fixed-dose heparin; Heparin dose; Pressure-wire
Core Tip	This study explores the safety and efficacy of fixed-dose vs weight-based unfractionated heparin dosing during diagnostic coronary physiology procedures. Among 128 patients, fixed-dose 5000 IU unfractionated heparin was associated with similarly low rates of bleeding and no thrombotic events compared to weight-based dosing. These findings suggest that a fixed-dose approach may be a safe and practical alternative in low-risk, physiology-only settings. The results may inform future research and support consideration of simplified anticoagulation strategies in stable patients undergoing diagnostic coronary physiology assessments.
Citation	Ralota KK, Tuncer D, Htun NM, Samuel R, Gupta V, Lew R, Layland J. Fixed vs weight-based heparin dosing in stable patients undergoing diagnostic coronary physiology studies. World J Cardiol 2025; In press

Received	2025-07-24 08:11
Peer-Review Started	2025-07-24 08:12
First Decision by Editorial Office Director	2025-08-20 07:34
Return for Revision	2025-08-20 07:34
Revised	2025-09-24 09:12
Publication Fee Transferred
Second Decision by Editor	2025-12-08 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-08 11:14
Articles in Press	2025-12-08 11:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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