Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	112327
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Ileal bile acid transporter inhibitors for chronic constipation in the elderly
Manuscript Source	Invited Manuscript
All Author List	Payila Satya Raghava Aneesh, Venkatesh Vaithiyam, Ravi Teja Reddy, Ashok Dalal and Sanjeev Sachdeva
Funding Agency and Grant Number
Corresponding Author	Venkatesh Vaithiyam, Assistant Professor, Department of Gastroenterology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research, New Delhi 110002, Delhi, India. venkateshvaithiyam172@gmail.com
Key Words	Ileal bile acid transporter; Elobixibat; Chronic constipation; Elderly; Colonic motility
Core Tip	This article offers a critical review of a recently published study on elobixibat in the treatment of chronic constipation in the elderly. The therapeutic arsenal against chronic constipation is expanding with new drugs and approaches. Elobixibat is a potent and selective inhibitor of the ileal bile acid transporter. It increases the colonic bile acid pool, which enhances colonic motility and secretion. Elobixibat improves bowel movements, stool consistency, and quality of life. Elobixibat is generally well-tolerated and effective in the elderly, as well as in patients with renal failure, heart failure, and Parkinson’s disease suffering from chronic constipation.
Citation	Aneesh PSR, Vaithiyam V, Reddy RT, Dalal A, Sachdeva S. Ileal bile acid transporter inhibitors for chronic constipation in the elderly. World J Gastrointest Pharmacol Ther 2025; In press

Received	2025-07-24 07:16
Peer-Review Started	2025-07-24 07:16
To Make the First Decision
Return for Revision	2025-09-03 07:18
Revised	2025-09-08 19:07
Second Decision	2025-11-24 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-24 08:57
Articles in Press	2025-11-24 08:57
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Typeset the Manuscript

ISSN	2150-5349 (online)
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