Publication Name	World Journal of Gastroenterology
Manuscript ID	112354
Country	China

Category	Medicine, General & Internal
Manuscript Type	Retrospective Cohort Study
Article Title	Development and validation of a predictive model for portal-systemic venous invasion grading in borderline resectable pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Fang-Fei Wang, Xiao-Di Dai, Xin Zhao, Qiang He and Shao-Cheng Lyu
Funding Agency and Grant Number
Corresponding Author	Shao-Cheng Lyu, Department of Hepatobiliary Pancreas and Spleen Surgery, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongtinan Road, Chaoyang District, Beijing 100020, China. shaocheng0502@163.com
Key Words	Borderline resectable pancreatic cancer; Portosystemic venous invasion; Pathological grading; Predictive model; Adventitial invasion; Muscularis propria invasion; Intimal invasion
Core Tip	This study developed a predictive model for pathological grading of portosystemic venous invasion depth in borderline resectable pancreatic cancer using routine preoperative indicators: Serum carbohydrate antigen 19-9, computed tomography circumferential involvement angle, and luminal compromise. The model achieved high accuracy (C-index 0.928) in stratifying venous invasion depth into adventitial, muscularis propria, or intimal invasion, which significantly affected prognosis (e.g., intimal invasion showed worst median overall survival of 9 months). This innovative tool enables preoperative risk quantification, guiding personalized therapy decisions such as neoadjuvant intensification or surgical planning, and addresses a critical unmet need in precision oncology for borderline resectable pancreatic cancer.
Citation	Wang FF, Dai XD, Zhao X, He Q, Lyu SC. Development and validation of a predictive model for portal-systemic venous invasion grading in borderline resectable pancreatic cancer. World J Gastroenterol 2025; In press

Received	2025-07-25 14:36
Peer-Review Started	2025-07-25 14:36
To Make the First Decision
Return for Revision	2025-08-07 09:44
Revised	2025-08-18 14:10
Second Decision	2025-10-13 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-13 06:40
Articles in Press	2025-10-13 06:40
Publication Fee Transferred	2025-08-21 01:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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