Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	112405
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Dachengqitang mitigates endoscopic retrograde cholangiopancreatography-induced pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Lei Zheng, Jin Wang, Mao-Qi Xu, Wen Jiang, Long Qian, Yu Ge, Mao-Kun Feng, Yi-Mei Zhu, Meng-Jun Wang, Sha-Sha Sun, Chang-Kuo Liu, Xiao-Ming Wang and Chao Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Research Project of Higher Education Institution of Anhui Provincial Department of Education 2022AH052638 and 2023AH040254
Corresponding Author	Xiao-Ming Wang, The Fifth Clinical Medical College, Anhui Medical University, No. 240 Jiuhua Middle Road, Jinghu District, Wuhu 230032, Anhui Province, China. wxm6901@126.com
Key Words	Dachengqitang; Post-ERCP acute pancreatitis; Postoperative complications; Intestinal mucosal barrier; M1 macrophages; Inflammation
Core Tip	Post-ERCP acute pancreatitis is a serious complication involving intestinal mucosal barrier dysfunction and excessive inflammation. This study integrates bioinformatics analysis with in vivo and in vitro models to investigate the protective effects of Dachengqitang (DCQT). The results demonstrate that DCQT enhances intestinal barrier integrity by upregulating ZO-1 and Occludin-1, reduces M1 macrophage activation, and promotes M2 polarization with increased IL-10 expression. DCQT also improves mitochondrial membrane potential in epithelial cells. These findings highlight the therapeutic potential of DCQT in managing postoperative inflammatory responses following ERCP.
Citation	Zheng L, Wang J, Xu MQ, Jiang W, Qian L, Ge Y, Feng MK, Zhu YM, Wang MJ, Sun SS, Liu CK, Wang XM, Zhang C. Dachengqitang mitigates endoscopic retrograde cholangiopancreatography-induced pancreatitis. World J Gastrointest Surg 2025; In press

Received	2025-09-12 08:21
Peer-Review Started	2025-09-12 08:21
First Decision by Editorial Office Director	2025-10-11 02:17
Return for Revision	2025-10-11 02:17
Revised	2025-10-28 13:54
Publication Fee Transferred	2025-11-03 03:12
Second Decision by Editor	2025-12-12 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-12 06:53
Articles in Press	2025-12-12 06:53
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Typeset the Manuscript

ISSN	1948-9366 (online)
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