Publication Name	World Journal of Psychiatry
Manuscript ID	112418
Country	China

Category	Psychology
Manuscript Type	Case Control Study
Article Title	Serum folate and brain-derived neurotrophic factor in pediatric autism spectrum disorder and their predictive role in illness severity
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Bin Chen, Xiao-Qin Xu and Yan-Hui Chen
Funding Agency and Grant Number	Funding Agency Grant Number Fujian Provincial Health Technology Project 2020QNA012
Corresponding Author	Yan-Hui Chen, Professor, Department of Pediatrics, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Gulou District, Fuzhou 350001, Fujian Province, China. deag0225@126.com
Key Words	Serum folate; Brain-derived neurotrophic factor; Autism spectrum disorder; Children; Illness severity; Receiver operating characteristic curve
Core Tip	We selected 53 autism spectrum disorder (ASD)-affected children and 50 healthy controls. Serum folate (SF) was down-regulated and brain-derived neurotrophic factor (BDNF) was up-regulated in ASD children. Both indices related closely to illness severity and could reflect therapeutic effectiveness. Moreover, low SF and high BDNF levels held predictive value for ASD aggravation in children.
Citation	Chen LB, Xu XQ, Chen YH. Serum folate and brain-derived neurotrophic factor in pediatric autism spectrum disorder and their predictive role in illness severity. World J Psychiatry 2025; In press

Received	2025-09-16 09:24
Peer-Review Started	2025-09-16 09:24
First Decision by Editorial Office Director	2025-10-13 03:08
Return for Revision	2025-10-13 03:08
Revised	2025-11-13 12:23
Publication Fee Transferred
Second Decision by Editor	2025-12-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-10 01:48
Articles in Press	2025-12-10 01:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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