Publication Name	World Journal of Methodology
Manuscript ID	112458
Country	India

Category	Ophthalmology
Manuscript Type	Case Report
Article Title	Are iris masses in lung carcinoma always a metastasis: Two case reports
Manuscript Source	Invited Manuscript
All Author List	Bhagabat Nayak, Prasanta Raghab Mohapatra, Koyel Chakraborty, Jayadev Nanda, Shri Haripriya, Satya Padmaja Mantha, Madhusmita Sethy and Bijnya Birajita Panda
Funding Agency and Grant Number
Corresponding Author	Bijnya Birajita Panda, Assistant Professor, Department of Ophthalmology, All India Institute Of Medical Sciences, AIIMS Road, Bhubaneswar 751019, Odisha, India. bigyan_panda@yahoo.co.in
Key Words	Iris nodules; Iris metastasis; Osimertinib; Lung adenocarcinoma; Small cell lung cancer; Case report
Core Tip	Though iris metastasis is rare in cases of systemic malignancies, a relatively rich vascular supply of uveal tissue makes it vulnerable compared to other ocular structures. Iris masses are often unilateral, may be painful and are vision-threatening. The lesion can be single or multiple, usually well-defined, inducing anterior chamber reaction leading to secondary glaucoma. With treatment advances like platinum doublet chemotherapy and targeted therapy for specific mutations, the disease progression can be arrested with alleviation of symptoms. However, some cases may require surgical intervention to manage the complications.
Citation	Nayak B, Mohapatra P, Chakraborty K, Nanda J, Haripriya S, Mantha SP, Sethy M, Panda BB. Are iris masses in lung carcinoma always a metastasis: Two case reports. World J Methodol 2025; In press

Received	2025-07-28 02:57
Peer-Review Started	2025-07-28 02:58
To Make the First Decision
Return for Revision	2025-08-19 09:16
Revised	2025-09-01 16:12
Second Decision	2025-11-14 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-14 05:34
Articles in Press	2025-11-14 05:34
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ISSN	2222-0682 (online)
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