Publication Name	World Journal of Diabetes
Manuscript ID	112475
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Fibroblast growth factor 1 alleviates diabetic nephropathy by reducing renal lipid accumulation in diabetic kidney
Manuscript Source	Unsolicited Manuscript
All Author List	Ying-Jian Li, He-Yu Ge, Gui-Gui Zhang, Hao-Yu Chen, Yu-Jia Xi, Kai Wang, Yin-Li Huang, Chi Zhang, Xia Fan and Xiao-Qing Yan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82470453 National Natural Science Foundation of China No. 82370832 Natural Science Foundation of Zhejiang Province No. LY22H020005 The Summit Advancement Disciplines of Zhejiang Province (Wenzhou Medical University-Pharmaceutics)
Corresponding Author	Xiao-Qing Yan, Associate Professor, School of Pharmaceutical Sciences, Wenzhou Medical University, University-Town, Wenzhou 325035, Zhejiang Province, China. yanxiaoqing@wmu.edu.cn
Key Words	Fibroblast growth factor 1; Diabetic nephropathy; Lipid accumulation; AMP-activated protein kinase; Human kidney-2; Carnitine palmitoyl transferase 1 alpha
Core Tip	Fibroblast growth factor 1 (FGF1) can effectively ameliorate diabetic nephropathy as reflected by improved renal function and alleviation of kidney morphological abnormalities. FGF1 alleviates renal lipid accumulation, as evidenced by decreased triglyceride content and repressed adipose differentiation-related protein expression, via inhibiting fatty acid uptake and promoting lipid catabolism in diabetic kidney. Mechanical studies demonstrated that FGF1 modulates renal lipid metabolism via restoring AMP-activated protein kinase activity and peroxisome proliferator-activated receptor alpha expression.
Citation	Li YJ, Ge HY, Zhang GG, Chen HY, Xi YJ, Wang K, Huang YL, Zhang C, Fan X, Yan XQ. Fibroblast growth factor 1 alleviates diabetic nephropathy by reducing renal lipid accumulation in diabetic kidney. World J Diabetes 2025; In press

Received	2025-07-28 14:35
Peer-Review Started	2025-08-04 06:33
To Make the First Decision
Return for Revision	2025-08-14 09:18
Revised	2025-10-12 13:02
Second Decision	2025-11-18 09:53
Accepted by Journal Editor-in-Chief	2025-11-24 10:13
Accepted by Executive Editor-in-Chief	2025-11-27 04:19
Articles in Press	2025-11-27 04:19
Publication Fee Transferred	2025-10-14 02:15
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ISSN	1948-9358 (online)
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