Publication Name	World Journal of Stem Cells
Manuscript ID	112476
Country	China

Category	Cell Biology
Manuscript Type	Letter to the Editor
Article Title	Insights into mitofusin-2 and endoplasmic reticulum stress regulation in adipose-derived mesenchymal stem cells senescence
Manuscript Source	Unsolicited Manuscript
All Author List	Fang Lin, Ke-Xin Ma and Xiao-Ting Liang
Funding Agency and Grant Number	Funding Agency Grant Number Shenzhen Science and Technology Program JCYJ20240813162036046
Corresponding Author	Xiao-Ting Liang, MD, PhD, Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China. liangxt@tongji.edu.cn
Key Words	Adipose-derived mesenchymal stem cells; Senescence; Endoplasmic reticulum stress; Nuclear factor erythroid-derived 2; Mitofusin-2
Core Tip	Fang’s study links the nuclear factor erythroid-derived 2-mitofusin-2 (MFN2) axis to endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells from obese mice. While the evidence for reduced nuclear factor erythroid-derived 2 and MFN2 suppression is compelling, key issues remain. The specific function of MFN2 in aging adipose-derived mesenchymal stem cells, its potential interaction with binding immunoglobulin protein, and its influence on endoplasmic reticulum stress remain unresolved. Future studies should elucidate the role of MFN2, establish direct biochemical evidence, and assess the therapeutic relevance of targeting this axis in insulin resistance using diet-induced obesity models.
Citation	Lin F, Ma KX, Liang XT. Insights into mitofusin-2 and endoplasmic reticulum stress regulation in adipose-derived mesenchymal stem cells senescence. World J Stem Cells 2025; In press

Received	2025-07-28 14:29
Peer-Review Started	2025-07-28 14:30
To Make the First Decision
Return for Revision	2025-09-04 07:16
Revised	2025-09-16 09:12
Second Decision	2025-10-20 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 10:37
Articles in Press	2025-10-20 10:37
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ISSN	1948-0210 (online)
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