Publication Name	World Journal of Gastroenterology
Manuscript ID	112483
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis
Manuscript Source	Unsolicited Manuscript
All Author List	Chi-Ying Xu, Zhi-Hua Zheng, Kun Yang, Ren-Ran Wu, Jia-Qing Cao and Jin-Yuan Duan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82360168 and 81960154 Natural Science Foundation of Jiangxi Province 20212BAB206020 Foundation of Health Commission of Jiangxi Province 202310024
Corresponding Author	Jin-Yuan Duan, Associate Chief Physician, PhD, Department of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 1519 Dongyue Avenue, Nanchang 330000, Jiangxi Province, China. duanjy2022@outlook.com
Key Words	Bariatric surgery; Mid to distal bowel resection; Gut microbiota; Bile acids; Gluconeogenesis
Core Tip	Distal small bowel resection with preservation of the terminal ileum (DBRPI) improves glucose tolerance and reduces weight in high-fat diet-fed rats. This effect is linked to altered gut microbiota and bile acids: Increased Prevotellaceae_NK3B31_group and 7-ketolithocholic acid (7-KLCA), alongside decreased Desulfovibrio fairfieldensis and α-muricholic acid. DBRPI upregulates ileal farnesoid X receptor (FXR) and glucagon-like peptide-1 (GLP-1) expression, and downregulates hepatic gluconeogenic genes. Critically, Prevotellaceae_NK3B31_group correlates positively with 7-KLCA and FXR, and negatively with glucose intolerance and gluconeogenesis. Thus, DBRPI likely improves glucose metabolism by activating the Prevotellaceae-mediated 7-KLCA-FXR pathway, enhancing GLP-1, and suppressing hepatic glucose production.
Citation	Xu CY, Zheng ZH, Yang K, Wu RR, Cao JQ, Duan JY. Distal small bowel resection with preservation of the terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis. World J Gastroenterol 2025; In press

Received	2025-07-29 05:04
Peer-Review Started	2025-07-29 05:05
To Make the First Decision
Return for Revision	2025-08-19 10:13
Revised	2025-09-02 03:07
Second Decision	2025-10-13 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-13 06:16
Articles in Press	2025-10-13 06:16
Publication Fee Transferred	2025-09-08 15:24
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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