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Articles in Press
10/13/2025 8:24:23 AM | Browse: 12 | Download: 4
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Immune regulation of Chidamide-induced Linc01010 accumulation in breast cancer cell death
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Han Han, Xiao-Yun Guo, Jia-Xin Wen, Xiao-Ming Zhao and Wei-Qiang Zhou |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Combination Foundation for Improving Innovation of Liaoning Province |
No. 2022-NLTS-14-01 |
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| Corresponding Author |
Wei-Qiang Zhou, Dean, PhD, Professor, Department of Pathogen Biology, Shenyang Medical College, No. 146 North Huanghe Street, Shenyang 110034, Liaoning Province, China. zhouwq@hotmail.com |
| Key Words |
Breast cancer; Linc01010; Chidamide; Mitogen-activated protein kinase kinase 6; Programmed death-ligand 1; Natural killer cells |
| Core Tip |
Breast cancer is a prevalent malignant tumor among women. This study screened the positive long chain non-coding RNA molecule Linc01010 which can counteract the pharmacological effects of Chidamide. While investigating the effects of the Chidamide-Linc01010-mitogen-activated protein kinase kinase 6-programmed death-ligand 1 axis on the immune cell line natural killer-92, we observed that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) secretion was significantly inhibited by this response axis. Furthermore, reducing TRAIL secretion within the tumor microenvironment diminished the death effects in breast cancer cells induced by Chidamide. Our study provides a robust foundation for improving the effectiveness of current anti-breast cancer medications and for identifying new targets related to drug resistance. |
| Citation |
Han H, Guo XY, Wen JX, Zhao XM, Zhou WQ. Immune regulation of Chidamide-induced Linc01010 accumulation in breast cancer cell death. World J Clin Oncol 2025; In press |
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Received |
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2025-07-29 12:59 |
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Peer-Review Started |
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2025-07-29 13:00 |
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To Make the First Decision |
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Return for Revision |
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2025-08-08 08:18 |
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Revised |
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2025-08-12 00:38 |
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Second Decision |
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2025-10-13 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-10-13 08:24 |
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Articles in Press |
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2025-10-13 08:24 |
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Publication Fee Transferred |
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2025-08-13 06:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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