Publication Name	World Journal of Cardiology
Manuscript ID	112541
Country	India

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Observational Study
Article Title	Pulmonary hypertension in patients with obstructive sleep apnea: Correlation with disease severity and quality of life
Manuscript Source	Invited Manuscript
All Author List	Praveen Kumar, Ajay Kumar Verma, Jyoti Bajpai, Sujita Kumar Kar, Akshyaya Pradhan, Surya Kant, Rajiv Garg, Santosh Kumar, Ram Avadh Singh Kushwaha, SK Verma, Darshan Kumar Bajaj, Anand Srivastava and Ankit katiyar
Funding Agency and Grant Number
Corresponding Author	Jyoti Bajpai, Associate Professor, FCCP, MD, Department of Respiratory Medicine, King George’s Medical University, Shahmina Road, Chowk, Lucknow 226003, Uttar Pradesh, India. jyotibajpai33@gmail.com
Key Words	Apnea-hypopnea index; Obstructive sleep apnea; Pulmonary hypertension; Quality of life; World Health Organisation Quality of Life Brief Version
Core Tip	Obstructive sleep apnea (OSA) is increasingly recognized as a contributor to cardiovascular morbidity, including pulmonary hypertension (PH). This present cross sectional study aimed to assess the prevalence and severity of PH in newly diagnosed OSA patients. Further, it evaluated its association with disease severity as well as quality of life (QoL). The 113 patients with de novo diagnosis with OSA underwent echocardiography to assess pulmonary artery pressures and completed the World Health Organisation Quality of Life Brief Version (WHOQOL-BREF) questionnaire. The prevalence of PH in patients with OSA was 71.68% and the prevalence increased with age and OSA severity (P < 0.01). There was positive correlation between apnea-hypopnea index and oxygen desaturation index with right ventricular systolic pressure (r = 0.677) and mean pulmonary artery pressure (r = 0.543). WHOQOL-BREF scores were significantly lower in PH patients, particularly in physical and psychological domains. PH is a prevalent and underdiagnosed complication of OSA that negatively impacts QoL. There is imminent need for integration of echocardiographic screening and QoL assessments into the routine management of OSA.
Citation	Kumar P, Verma AK, Bajpai J, Kar SK, Pradhan A, Kant S, Garg R, Kumar S, Kushwaha RAS, Verma S, Bajaj DK, Srivastava A, Katiyar A. Pulmonary hypertension in patients with obstructive sleep apnea: Correlation with disease severity and quality of life. World J Cardiol 2025; In press

Received	2025-07-31 02:06
Peer-Review Started	2025-07-31 02:06
To Make the First Decision
Return for Revision	2025-08-22 09:22
Revised	2025-09-01 16:07
Second Decision	2025-11-20 23:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-21 05:48
Articles in Press	2025-11-21 05:48
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ISSN	1949-8462 (online)
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