Publication Name	World Journal of Gastroenterology
Manuscript ID	112559
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Construction and efficacy validation of a multi-parametric contrast-enhanced ultrasound nomogram model for discriminating hepatic inflammatory lesions from malignancies
Manuscript Source	Unsolicited Manuscript
All Author List	Si-Jie Mou, San-Mei Yu, Yan-Ni Xiang and Bo Tang
Funding Agency and Grant Number
Corresponding Author	Bo Tang, Ultrasound Department, Taizhou First People's Hospital, No. 218 Hengjie Road, Huangyan District, Taizhou 318020, Zhejiang Province, China. tangbo19852025@163.com
Key Words	Hepatic; Contrast-enhanced ultrasound; Machine learning; Differential diagnosis; SHapley Additive exPlanations; Inflammatory lesions; Malignant tumors
Core Tip	We developed and externally tested (within an independent test set) a multi-parametric contrast-enhanced ultrasound-based, SHapley Additive exPlanations-interpretable machine learning nomogram to differentiate hepatic inflammatory lesions from malignant tumors. Logistic regression showed the best overall generalization (area under the curve = 0.965; accuracy = 94.35%) and significantly outperformed alpha-fetoprotein and Model for End-Stage Liver Disease scores. Blood flow signals and wash-in time, as the key driving factors of model decision-making, can offer an intuitive and clinically relevant diagnostic reference basis.
Citation	Mou SJ, Yu SM, Xiang YN, Tang B. Construction and efficacy validation of a multi-parametric contrast-enhanced ultrasound nomogram model for discriminating hepatic inflammatory lesions from malignancies. World J Gastroenterol 2026; In press

Received	2025-12-05 08:36
Peer-Review Started	2025-12-05 08:36
First Decision by Editorial Office Director	2025-12-25 08:52
Return for Revision	2025-12-25 08:52
Revised	2026-01-20 08:21
Publication Fee Transferred
Second Decision by Editor	2026-02-25 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-25 07:44
Articles in Press	2026-02-25 07:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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