Publication Name	World Journal of Gastroenterology
Manuscript ID	112577
Country	China

Category	Nutrition & Dietetics
Manuscript Type	Randomized Controlled Trial
Article Title	Multistrain probiotics alleviate gastrointestinal symptoms during bismuth quadruple therapy for Helicobacter pylori infection
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Jun Liu, Yue-Ming Zhao, Qing-Qing Xie, Min-Chan Wu, Yun-Feng Pan, Hao-Kun Yan, Xiao-Xi Shan, Wen-Ting Xu, Yang-Ling Liu, Cai-Xia Peng, Xiao-Mei Zhang and Qian Lin
Funding Agency and Grant Number	Funding Agency Grant Number the Hyproca Nutrition Co., Ltd.
Corresponding Author	Qian Lin, MD, PhD, Professor, Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, No. 172 Tongzipo Road, Yuelu District, Changsha 410078, Hunan Province, China. linqian@csu.edu.cn
Key Words	Helicobacter pylori infection; Bismuth quadruple therapy; Multistrain probiotics; Gastrointestinal symptoms; Randomised controlled trial
Core Tip	In this randomized, double-blind, placebo-controlled trial involving 174 adults, a 4-week multistrain probiotics formula mainly containing five Bifidobacterium and Lactobacillus species added to bismuth quadruple therapy for Helicobacter pylori infection significantly reduced reflux, dyspepsia and diarrhea scores at weeks 4-8 without affecting eradication rates. Probiotics are a safe adjunct to ease antibiotic-associated gastrointestinal symptoms.
Citation	Liu WJ, Zhao YM, Xie QQ, Wu MC, Pan YF, Yan HK, Shan XX, Xu WT, Liu YL, Peng CX, Zhang XM, Lin Q. Multistrain probiotics alleviate gastrointestinal symptoms during bismuth quadruple therapy for Helicobacter pylori infection. World J Gastroenterol 2025; In press

Received	2025-07-31 03:58
Peer-Review Started	2025-07-31 03:58
To Make the First Decision
Return for Revision	2025-08-14 11:21
Revised	2025-09-04 15:50
Second Decision	2025-10-13 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-13 06:03
Articles in Press	2025-10-13 06:03
Publication Fee Transferred	2025-09-08 00:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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