Publication Name	World Journal of Clinical Cases
Manuscript ID	112585
Country	Italy

Category	Neurosciences
Manuscript Type	Systematic Reviews
Article Title	Phenotypic and functional characteristics of pituitary adenoma stem cells
Manuscript Source	Invited Manuscript
All Author List	Edoardo Agosti, Lorenzo Gelmini, Pier Paolo Panciani, Alessandro Fiorindi, Marco Maria Fontanella, Francesco Tengattini, Luca Denaro, Caterina Gagliano, Daniele Tognetto and Marco Zeppieri
Funding Agency and Grant Number
Corresponding Author	Marco Zeppieri, MD, PhD, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words	Pituitary neuroendocrine tumors; Stem cells; Tumorigenesis; Therapy resistance; Pituitary adenoma stem cells; Pathway
Core Tip	Pituitary adenoma stem cells are a functionally distinct subpopulation within pituitary neuroendocrine tumors, exhibiting stem-like traits such as self-renewal, multipotency, and resistance to dopamine agonists and somatostatin analogs. This systematic review consolidates evidence from 34 studies, highlighting the expression of key markers like SRY-related HMG-box transcription factor 2, CD133, and Nestin, and the involvement of dysregulated pathways including Wnt/beta-catenin, Notch, Sonic hedgehog. Pituitary adenoma stem cells are implicated in tumorigenesis, invasion, and recurrence, making them compelling targets for future therapies aimed at overcoming resistance and preventing relapse in pituitary neuroendocrine tumors.
Citation	Agosti E, Gelmini L, Panciani PP, Fiorindi A, Fontanella MM, Tengattini F, Denaro L, Gagliano C, Tognetto D, Zeppieri M. Phenotypic and functional characteristics of pituitary adenoma stem cells. World J Clin Cases 2025; In press

Received	2025-07-31 02:31
Peer-Review Started	2025-07-31 02:31
First Decision by Editorial Office Director	2025-08-19 09:11
Return for Revision	2025-08-19 09:11
Revised	2025-08-20 06:08
Publication Fee Transferred
Second Decision by Editor	2025-12-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-10 02:55
Articles in Press	2025-12-10 02:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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