Publication Name	World Journal of Diabetes
Manuscript ID	112621
Country	China

Category	Critical Care Medicine
Manuscript Type	Retrospective Study
Article Title	Combined assessment with stress hyperglycemia ratio and time in range: Associations with twenty-eight-day mortality in surgical intensive care unit patients
Manuscript Source	Unsolicited Manuscript
All Author List	Shuang Liu, Bai-Ge Cao, Yue Ma, Jin-Fang Xu, Quan-Hong Zhou and Cong-Rong Wang
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Science and Technology Development Funds 22410713200 The Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0509206 National Natural Science Foundation of China 82471893 Key Discipline Project of Hongkou District Health Commission HKLCFC202403 Research fund from Shanghai Fourth People’s Hospital sykyqd01801 Research fund from Shanghai Fourth People’s Hospital SY-XKZT-2021-1001
Corresponding Author	Cong-Rong Wang, PhD, Professor, Department of Endocrinology and Metabolism, Shanghai Fourth People’s Hospital Affiliated to Tongji University, No. 1279 Sanmen Road, Shanghai 200434, China. crwang@tongji.edu.cn
Key Words	Surgical intensive care unit; Stress hyperglycemia ratio; Time in range; Twenty-eight-day mortality; Hyperglycemia
Core Tip	While the stress hyperglycemia ratio (SHR) has been widely examined as a marker of acute glycemic disturbance, prior studies have largely emphasized its independent prognostic value, often neglecting its interaction with longitudinal glycemic control indicators. In this study, we evaluated the combined effect of SHR and time in range (TIR) on 28-day mortality in surgical ICU patients. We found that patients with both elevated SHR and reduced TIR exhibited the highest risk of death, with a 2.37-fold increase compared to those with low SHR and high TIR. These findings highlight the prognostic relevance of both acute hyperglycemia and persistent glycemic dysregulation, and emphasize the potential value of integrated glucose management strategies in critically ill patients.
Citation	Liu S, Cao BG, Ma Y, Xu JF, Zhou QH, Wang CR. Combined assessment with stress hyperglycemia ratio and time in range: Associations with twenty-eight-day mortality in surgical intensive care unit patients. World J Diabetes 2025; In press

Received	2025-08-01 03:32
Peer-Review Started	2025-08-05 00:11
To Make the First Decision
Return for Revision	2025-09-02 03:26
Revised	2025-09-13 15:37
Second Decision	2025-11-28 03:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-28 10:24
Articles in Press	2025-11-28 10:24
Publication Fee Transferred	2025-09-30 02:25
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Typeset the Manuscript

ISSN	1948-9358 (online)
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