Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	112630
Country	Italy

Category	Surgery
Manuscript Type	Letter to the Editor
Article Title	Right patient approach to experimental stromal cell therapies for gastrointestinal tumors
Manuscript Source	Invited Manuscript
All Author List	Francesca Vescio, Silvia Curcio, Isabella Aquila, Michele Ammendola and Alessandro Pasquale Tarallo
Funding Agency and Grant Number
Corresponding Author	Michele Ammendola, MD, Department of Experimental and Clinical Medicine, Digestive Surgery Unit, University "Magna Graecia" Medical School, University Hospital "R. Dulbecco", Viale Europa, Catanzaro 88100, Italy. michele.ammendola@libero.it
Key Words	Experimental therapies; Surgery; Non-standardized treatment; Gastrointestinal tumor; Informed consent
Core Tip	Experimental therapies targeting immune stromal cells in the treatment of gastrointestinal tumors pose surgical and medico-legal challenges. These treatments, being innovative, require that the patient's informed consent represent a truly relational and cognitive process, based on understanding and free choice. It is essential that the patient be able to understand the experimental nature of the therapy, the potential benefits and risks, as well as the implications for their health and personal dignity. Furthermore, if the patient participates in a non-standardized treatment, they must be aware that the outcomes, positive or negative, are not yet known with certainty.
Citation	Vescio F, Curcio S, Aquila I, Ammendola M, Tarallo AP. Right patient approach to experimental stromal cell therapies for gastrointestinal tumors. World J Gastrointest Oncol 2025; In press

Received	2025-08-06 14:51
Peer-Review Started	2025-08-06 14:52
To Make the First Decision
Return for Revision	2025-08-17 07:53
Revised	2025-08-30 18:16
Second Decision	2025-11-18 01:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-18 07:43
Articles in Press	2025-11-18 07:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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