Publication Name	World Journal of Methodology
Manuscript ID	112691
Country	Morocco

Category	Immunology
Manuscript Type	Minireviews
Article Title	Methodological strategies for mapping HLA susceptibility loci in vitiligo: A focused minireview
Manuscript Source	Invited Manuscript
All Author List	Abdellatif Bouayad
Funding Agency and Grant Number
Corresponding Author	Abdellatif Bouayad, Associate Professor, Laboratory of Immunology, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, 4867 Oujda l’Université, Oujda-Angad 4867, Oriental, Morocco. a.bouayad@ump.ac.ma
Key Words	Vitiligo; Human leukocyte antigen; HLA typing; Case-control studies; Family studies; Genome-wide association studies
Core Tip	Sequencing-based HLA typing offers higher resolution and can detect novel HLA alleles in vitiligo that may be missed by serological or conventional molecular methods. While gene expression and association studies are susceptible to false positives, rigorous genome-wide association studies incorporating quality control, population stratification adjustment, and replication enhance reliability. Computational modeling of the HLA-peptide-TCR complex holds promise for guiding the development of targeted precision immunotherapies.
Citation	Bouayad A. Methodological strategies for mapping HLA susceptibility loci in vitiligo: A focused minireview. World J Methodol 2025; In press

Received	2025-08-04 00:55
Peer-Review Started	2025-08-04 00:55
To Make the First Decision
Return for Revision	2025-08-08 08:56
Revised	2025-08-11 22:04
Second Decision	2025-11-05 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-05 06:25
Articles in Press	2025-11-05 06:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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