Publication Name	World Journal of Methodology
Manuscript ID	112692
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Clinical Trial
Article Title	Open-label randomized controlled study of salt-restricted vs salt-unrestricted diet in cirrhosis patients with hyponatremia
Manuscript Source	Invited Manuscript
All Author List	Sudheer Marrapu, Ramesh Kumar, Divendu Bhushan, Sudhir Kumar, Abhishek Kumar, Rajeev N Priyadarshi and Utpal Anand
Funding Agency and Grant Number
Corresponding Author	Ramesh Kumar, Additional Professor, DM, Head, Department of Gastroenterology, All India Institute of Medical Sciences, Patna 801507, Bihar, India. docrameshkr@gmail.com
Key Words	Dietary salt; Sodium restriction; Cirrhosis; Hyponatremia; Acute kidney injury; Nutrition; Sarcopenia
Core Tip	This study highlights the potential harm of salt restriction in cirrhotic patients with moderate to severe hyponatremia. Patients in the salt-restricted diet group (5 g/day) had a significantly higher risk of acute kidney injury, poorer nutritional and hemodynamic profiles, and increased short-term mortality compared to those in the salt-unrestricted diet group (10 g/day). Importantly, no significant improvement in ascites control was observed with salt restriction. These results question the routine use of salt restriction in this subgroup and emphasize the need for a more tailored dietary approach to optimize renal function, nutrition, and survival outcomes in hyponatremic cirrhotic patients.
Citation	Marrapu S, Kumar R, Bhushan D, Kumar S, Kumar A, Priyadarshi RN, Anand U. Open-label randomized controlled study of salt-restricted vs salt-unrestricted diet in cirrhosis patients with hyponatremia. World J Methodol 2026; In press

Received	2025-08-04 08:31
Peer-Review Started	2025-08-04 08:31
First Decision by Editorial Office Director	2025-08-14 03:05
Return for Revision	2025-08-14 08:52
Revised	2025-08-22 16:09
Publication Fee Transferred
Second Decision by Editor	2026-01-09 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-09 13:52
Articles in Press	2026-01-09 13:52
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Typeset the Manuscript

ISSN	2222-0682 (online)
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