Publication Name	World Journal of Stem Cells
Manuscript ID	112702
Country	China

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Review
Article Title	Post-translational modifications in the oral microenvironment: Stem cell regulation from periodontal regeneration to oral cancer therapy
Manuscript Source	Invited Manuscript
All Author List	Wei Liu, Yuan-Yuan Yang and Zhuo-Jin Shi
Funding Agency and Grant Number
Corresponding Author	Zhuo-Jin Shi, DDS, School/Hospital of Stomatology, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou 310053, Zhejiang Province, China. shizhuojin@yeah.net
Key Words	Dental-derived mesenchymal stem cells; Post-translational modifications; Periodontal regeneration; Oral squamous cell carcinoma; Cancer stem-cell plasticity
Core Tip	Post-translational modifications act as dynamic molecular codes that steer dental-derived mesenchymal stem cells through a continuum from periodontal regeneration to oral squamous cell carcinoma stem-cell plasticity. This review integrates single-cell and spatial multi-omics evidence to map a sequential cascade - acetylation, crotonylation, phosphorylation, trimethylation, ubiquitination and N6-methyladenosine RNA methylation - that reprograms lineage commitment, immune evasion and therapy resistance. Identifying tractable post-translational modification enzymes (e.g., general control non-depressible 5, enhancer of zeste homolog 2, methyltransferase-like 3) clarifies actionable levers for regeneration and oncology.
Citation	Liu W, Yang YY, Shi ZJ. Post-translational modifications in the oral microenvironment: Stem cell regulation from periodontal regeneration to oral cancer therapy. World J Stem Cells 2025; In press

Received	2025-08-04 06:37
Peer-Review Started	2025-08-04 06:37
To Make the First Decision
Return for Revision	2025-09-08 09:52
Revised	2025-09-16 13:07
Second Decision	2025-11-05 02:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-06 09:56
Articles in Press	2025-11-06 09:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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