Publication Name	World Journal of Obstetrics and Gynecology
Manuscript ID	112710
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Navigating heart failure medications in obstetric practice
Manuscript Source	Invited Manuscript
All Author List	Xin Cheng, Xing-Lei Yin, Ya-Qi Shan, Shuai-Yan Wang, You-Bing Xia, Bin Xu and Tian-Cheng Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Key R and D Program of China No. 2022YFC3500704 National Natural Science Foundation of China No. 82305376 Project of Supporting Young Scientific and Technological Talents in Jiangsu Province in 2024 No. JSTJ-2024-380 College Students' Innovative Entrepreneurial Training Plan Program No. 202310315029Z
Corresponding Author	Tian-Cheng Xu, CEO, Chairman, Head, MD, PhD, President, Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn
Key Words	Obstetric practice; Pregnancy heart failure; Peripartum cardiomyopathy; Preeclampsia; Drug management; Physiological changes during pregnancy; Pregnancy pharmacokinetics
Core Tip	Heart failure (HF) in pregnancy poses significant maternal and fetal risks, exacerbated by physiological adaptations and underlying cardiac conditions. This mini-review delineates the pathophysiology, pharmacokinetics, and pharmacological management of pregnancy-related HF, emphasizing the safety and efficacy of medications like beta-blockers, diuretics, and digoxin. Concurrently, it categorically outlines contraindicated medications, including renin-angiotensin system inhibitors (angiotensin-converting enzyme inhibitors, angiotensin II type 1 receptor blockers), angiotensin receptor-neprilysin inhibitors, and mineralocorticoid receptor antagonists due to their potential teratogenic effects. It highlights multidisciplinary care models and the need for further research to optimize therapeutic strategies and improve maternal-fetal outcomes.
Citation	Cheng X, Yin XL, Shan YQ, Wang SY, Xia YB, Xu B, Xu TC. Navigating heart failure medications in obstetric practice. World J Obstet Gynecol 2025; In press

Received	2025-08-04 05:48
Peer-Review Started	2025-08-04 05:49
To Make the First Decision
Return for Revision	2025-08-25 07:30
Revised	2025-08-29 04:00
Second Decision	2025-11-20 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-20 06:09
Articles in Press	2025-11-20 06:09
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ISSN	2218-6220 (online)
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