Publication Name	World Journal of Gastroenterology
Manuscript ID	112725
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Autophagy related RHEB-CSF1R complex promotes tumor metastasis via advancing phosphorylation levels of PI3K, AKT, mTOR in pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Qian-Xi Deng, Kun Yang, Jin He, Jun-Feng Li, Xiao-Qing Li, Long Zou, Yi-Ming Li, Shu-Man Xu, Zheng Jiang and Lin-Ju Wu
Funding Agency and Grant Number	Funding Agency Grant Number Sichuan Medical and Health Care Promotion Institute Youth Research Project KY2023QN0129 Research Project of Early Gastrointestinal Cancer Physician Co-Growth Program GTCZ-2023-SC-06 The Third Hospital of Mianyang Research Project 202206
Corresponding Author	Lin-Ju Wu, Chief Physician, Department of Anesthesiology, The Third Hospital of Mianyang, Sichuan Mental Health Center, No. 190 East Jiannan Road, Youxian District, Mianyang 621000, Sichuan Province, China. wulinju2149@mysyy.cn
Key Words	Ras homolog enriched in brain; Colony stimulating factor 1 receptor; Autophagy; Phosphorylation of phosphatidylinositol 3-kinase; AKT serine/threonine kinase 1; Mammalian target of rapamycin; Pancreatic cancer; Metastasis
Core Tip	Ras homolog enriched in brain (RHEB), small GTPases, play a crucial role in regulating neuronal activity and have gained attention for their implications in cancer development, particularly in pancreatic cancer (PC). Clarifying the precise mechanism through which the autophagy-related gene RHEB promotes PC metastasis holds the potential for improving prognosis as well as for developing new prevention and treatment strategies. This study aims to elucidate the role of the autophagy-related gene RHEB in PC metastasis.
Citation	Deng QX, Yang K, He J, Li JF, Li XQ, Zou L, Li YM, Xu SM, Jiang Z, Wu LJ. Autophagy related RHEB-CSF1R complex promotes tumor metastasis via advancing phosphorylation levels of PI3K, AKT, mTOR in pancreatic cancer. World J Gastroenterol 2026; In press

Received	2025-09-03 08:45
Peer-Review Started	2025-09-03 08:46
First Decision by Editorial Office Director	2025-09-25 03:22
Return for Revision	2025-09-25 03:22
Revised	2025-10-21 17:03
Publication Fee Transferred	2025-11-05 11:15
Second Decision by Editor	2026-01-16 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-16 07:26
Articles in Press	2026-01-16 07:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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