Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	112742
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients
Manuscript Source	Unsolicited Manuscript
All Author List	Zhan-Wen Li, Zhe Liu and Sheng-Qun Liu
Funding Agency and Grant Number
Corresponding Author	Sheng-Qun Liu, Chief Physician, Department of Anesthesia and Perioperative Medicine, Henan Provincial People’s Hospital (Zhengzhou University People’s Hospital), No. 7 Weiwu Road, Zhengzhou 450003, Henan Province, China. liushengqunhx@163.com
Key Words	Obesity; Rocuronium; Skeletal muscle index; Population pharmacokinetics; Individualized dosing; Colorectal cancer; Sarcopenia
Core Tip	This study established a population pharmacokinetic model of rocuronium in obese patients with colorectal cancer, incorporating skeletal muscle index to explore its effect on drug distribution volume. Using nonlinear mixed-effects modeling and Monte Carlo simulation, we developed an individualized dosing strategy based on muscle mass. The findings reveal that skeletal muscle index is a significant covariate influencing rocuronium pharmacokinetic, providing a scientific basis for optimizing anesthetic dosing in obese surgical patients and enhancing patient safety during colorectal cancer surgery.
Citation	Li ZW, Liu Z, Liu SQ. Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients. World J Gastrointest Oncol; 2025; In press

Received	2025-08-15 08:20
Peer-Review Started	2025-08-15 08:20
First Decision by Editorial Office Director	2025-09-09 09:26
Return for Revision	2025-09-09 09:26
Revised	2025-09-22 13:59
Publication Fee Transferred	2025-09-24 02:11
Second Decision by Editor	2025-12-02 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-02 10:15
Articles in Press	2025-12-02 10:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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