Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	112753
Country	Malaysia

Category	Oncology
Manuscript Type	Minireviews
Article Title	Interlaced roles of mitochondrial DNA in colorectal cancer: Liquid-biopsy biomarkers, nuclear mtDNA-driven genomic instability, and mito-encoded micro peptide signaling
Manuscript Source	Invited Manuscript
All Author List	Thai-Hau Koo, Xue-Bin Leong, Yi-Lin Lee, Firdaus Hayati and Andee Dzulkarnaen Zakaria
Funding Agency and Grant Number
Corresponding Author	Andee Dzulkarnaen Zakaria, Department of Surgery, Hospital Pakar Universiti Sains Malaysia, School of Medical Sciences, Jalan Raja Perempuan Zainab 2, Kubang Kerian 16150, Kelantan, Malaysia. andee@usm.my
Key Words	Proteomic; Multi-omics; Gastrointestinal malignancy; Precision oncology; Biomarker discovery; Therapeutic resistance
Core Tip	This minireviews highlights the emerging roles of mitochondrial DNA (mtDNA) in colorectal cancer beyond its role in energy metabolism. Three interrelated domains are focused on in this paper: (1) Cell-free mtDNA as a liquid biopsy biomarker of exceptional sensitivity; (2) Nuclear mtDNA fragments as a component of genomic instability; and (3) Mitochondria-derived peptides, such as humanin and mitochondrial open reading frame of the 12S rRNA type-c, as regulators of tumour behaviour. These insights reveal novel diagnostic and therapeutic potential by targeting mitochondrial-nuclear cross-talk in colorectal cancer.
Citation	Koo TH, Leong XB, Lee YL, Hayati F, Zakaria AD. Interlaced roles of mitochondrial DNA in colorectal cancer: Liquid-biopsy biomarkers, nuclear mtDNA-driven genomic instability, and mito-encoded micro peptide signaling. World J Gastrointest Oncol 2025; In press

Received	2025-08-05 00:49
Peer-Review Started	2025-08-05 00:49
To Make the First Decision
Return for Revision	2025-08-22 08:31
Revised	2025-09-28 12:36
Second Decision	2025-11-12 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-12 09:57
Articles in Press	2025-11-12 09:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com