Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	112754
Country	India

Category	Anesthesiology
Manuscript Type	Minireviews
Article Title	Gut-brain axis and post-operative cognitive dysfunction: A multifactorial perspective on microbiota, inflammation, and cognitive health
Manuscript Source	Invited Manuscript
All Author List	Rhythm Joshi, Nishkarsh Gupta, Anju Gupta, Puneet Khanna, Nishant Verma and Simran Kaur
Funding Agency and Grant Number
Corresponding Author	Anju Gupta, Assistant Professor, Associate Professor, MD, Department of Anesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi 110029, Delhi, India. dranjugupta09@gmail.com
Key Words	Gut-brain axis; Post-operative cognitive dysfunction; Gut microbiota; Akkermansia muciniphila; Neuroinflammation; Short-chain fatty acids; Gut dysbiosis; Cognitive outcomes after surgery; Probiotic intervention; Microbiota-based targeted therapy
Core Tip	This review explores the important connection between gut health and brain function, especially in patients recovering from surgery. It focuses on how disturbances in gut microbes after surgery can lead to inflammation, impaired gut barrier function, and memory issues—collectively known as post-operative cognitive dysfunction. The article highlights growing evidence that restoring gut balance using probiotics and other microbiota-based therapies may help reduce inflammation and support better cognitive recovery. By drawing attention to the gut-brain link, this review opens up new possibilities for non-invasive strategies to protect the brain and improve mental clarity in post-surgical patients.
Citation	Joshi R, Gupta N, Gupta A, Khanna P, Verma N, Kaur DS. Gut-brain axis and post-operative cognitive dysfunction: A multifactorial perspective on microbiota, inflammation, and cognitive health. World J Gastrointest Pharmacol Ther 2025; In press

Received	2025-08-05 00:59
Peer-Review Started	2025-08-05 00:59
To Make the First Decision
Return for Revision	2025-08-27 08:17
Revised	2025-09-11 06:33
Second Decision	2025-11-26 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-26 09:12
Articles in Press	2025-11-26 09:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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