Publication Name	World Journal of Biological Chemistry
Manuscript ID	112768
Country	Mexico

Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma
Manuscript Source	Invited Manuscript
All Author List	Enrique Oropeza-Martínez, Eva G Palacios Serrato, Sayra X Zamora-Salas, Norma A Lira-Rodríguez, Siankaan HZ López-Mignon, Maximo B Martinez-Benitez and Angeles C Tecalco-Cruz
Funding Agency and Grant Number	Funding Agency Grant Number Colegio de Ciencia y Tecnología de la Universidad Autónoma de la Ciudad de México CCYT-2025-CON-11
Corresponding Author	Angeles C Tecalco-Cruz, Full Professor, PhD, Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Colonia Del valle, San Lorenzo 290, Mexico 03100, Mexico. angeles.tecalco@uacm.edu.mx
Key Words	Glioblastoma; Interferon gamma; Janus kinases; Interferon-stimulated genes; Signal transducer and activator of transcription 1; Interferon regulatory factor 1; B7-H1 antigen; Indoleamine-2,3-dioxygenase; Interferon-stimulated gene 15; Signal transduction
Core Tip	This review examines the characteristics and functions of five genes induced by interferon-gamma—signal transducer and activator of transcription 1, interferon regulatory factor 1, programmed death-ligand 1, indoleamine 2,3-dioxygenase 1, and interferon-stimulated gene 15—that participate in various mechanisms that promote glioblastoma, a highly aggressive brain tumor; therefore, investigating these genes could contribute to the identification of potential biomarkers and therapeutic targets.
Citation	Oropeza-Martínez E, Palacios Serrato EG, Zamora-Salas SX, Lira-Rodríguez NA, Lopez-Mignon SHZ, Martinez-Benitez MB, Tecalco-Cruz AC. Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma. World J Biol Chem 2025; In press

Received	2025-08-05 09:34
Peer-Review Started	2025-08-05 09:35
To Make the First Decision
Return for Revision	2025-08-27 06:45
Revised	2025-09-08 15:22
Second Decision	2025-11-26 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-26 11:35
Articles in Press	2025-11-26 11:35
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ISSN	1949-8454 (online)
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