Publication Name	World Journal of Diabetes
Manuscript ID	112799
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Longitudinal assessment of pancreatic exocrine dysfunction in type 1 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Federico Bolado, Lucía Zabalza, Joaquín de-Carlos, Ibai Tamayo-Rodríguez, Carlos Prieto-Martínez and Nerea Hervás-Palacios
Funding Agency and Grant Number
Corresponding Author	Federico Bolado, Associate Professor, MD, PhD, Department of Gastroenterology, Hospital Universitario de Navarra, Calle Irunlarrea 3, Pamplona 31003, Navarre, Spain. federico.bolado@unavarra.es
Key Words	Type 1 diabetes; Diabetes-related complications; Pancreatic exocrine function; Fecal elastase-1; Exocrine pancreatic insufficiency
Core Tip	This is the first study to investigate exocrine pancreatic dysfunction in individuals with type 1 diabetes (T1D) using fecal elastase in a longitudinal design. Our findings suggest that pancreatic exocrine function is frequently altered in T1D and may decline over time. However, the underlying pathophysiology remains unclear, and the clinical impact appears limited. Therefore, low fecal elastase levels in T1D should be interpreted with caution to avoid overdiagnosis and unnecessary treatment.
Citation	Bolado F, Zabalza L, de-Carlos J, Tamayo-Rodríguez I, Prieto-Martínez C, Hervás-Palacios N. Longitudinal assessment of pancreatic exocrine dysfunction in type 1 diabetes. World J Diabetes 2025; In press

Received	2025-08-22 09:14
Peer-Review Started	2025-08-22 09:15
To Make the First Decision
Return for Revision	2025-09-06 14:10
Revised	2025-09-16 15:03
Second Decision	2025-10-30 05:38
Accepted by Journal Editor-in-Chief	2025-11-02 18:26
Accepted by Executive Editor-in-Chief	2025-11-05 07:18
Articles in Press	2025-11-05 07:18
Publication Fee Transferred	2025-09-24 18:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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