Publication Name	World Journal of Clinical Oncology
Manuscript ID	112801
Country	Egypt

Category	Medicine, General & Internal
Manuscript Type	Case Control Study
Article Title	Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms
Manuscript Source	Invited Manuscript
All Author List	Dalia E Sherief, Nahla Nosair, Aya Mohammed Abdelhameed, Emad Sadaka, Amira A. A Othman and Rasha Elgamal
Funding Agency and Grant Number
Corresponding Author	Amira A. A Othman, Chief Physician, MD, PhD, Professor, Department of Internal Medicine, Suez University, Cairo-Suez Road, Suez 43511, As Suways, Egypt. amira.othman@med.suezuni.edu.eg
Key Words	Lymphoproliferative neoplasms; Programmed death ligand-1; Programmed death 1; C-X-C motif chemokine receptor 3; Systemic immune-inflammation index; Systemic inflammation response index; Inflammatory biomarkers
Core Tip	This case-control study explores the prognostic value of programmed death ligand-1/programmed death 1 co-expression and C-X-C motif chemokine receptor (CXCR) 3-driven immune signatures in Egyptian patients with lymphoproliferative neoplasms. By integrating flow cytometric analysis with systemic inflammation indices - systemic immune-inflammation index and systemic inflammation response index - the study identifies novel biomarker panels predictive of disease stage, recurrence, and survival. Findings support the use of programmed death ligand-1/CXCR3 and programmed death 1/CXCR3 as clinically relevant tools for risk stratification in resource-limited settings, paving the way for personalized management of lymphoproliferative neoplasms.
Citation	Sherief DE, Nosair N, Abdelhameed AM, Sadaka E, Othman AAA, Elgamal R. Prognostic significance of PD-L1/PD-1 co-expression and CXCR3-driven inflammatory signatures in Egyptian patients with lymphoproliferative neoplasms. World J Clin Oncol 2025; In press

Received	2025-08-06 15:05
Peer-Review Started	2025-08-06 15:05
To Make the First Decision
Return for Revision	2025-09-01 08:36
Revised	2025-09-03 18:02
Second Decision	2025-11-17 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-17 09:30
Articles in Press	2025-11-17 09:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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