Publication Name	World Journal of Hepatology
Manuscript ID	112821
Country	Japan

Category	Medicine, General & Internal
Manuscript Type	Review
Article Title	Evaluation methods of hepatic steatosis: From conventional techniques to emerging biomarkers
Manuscript Source	Invited Manuscript
All Author List	Kengo Moriyama
Funding Agency and Grant Number
Corresponding Author	Kengo Moriyama, MD, PhD, Professor, Department of Clinical Health Science, Tokai University School of Medicine, 1838 Ishikawa-machi, Hachioji 1920032, Tōkyō, Japan. kengomoriyama@tokai.ac.jp
Key Words	Metabolic dysfunction-associated steatotic liver disease; Hepatic steatosis; Magnetic resonance imaging-derived proton density fat fraction; Controlled attenuation parameter; Blood-based biomarkers; Artificial intelligence; DNA methylation
Core Tip	This review provides a comprehensive overview of hepatic steatosis evaluation methods, ranging from conventional ultrasound and liver biopsy to advanced techniques such as magnetic resonance imaging-derived proton density fat fraction, attenuation-based ultrasound, and emerging blood-based and epigenetic biomarkers. By integrating multimodal diagnostic strategies, including artificial intelligence-assisted imaging and methylation profiling, clinicians can improve the diagnosis, risk stratification, and therapeutic monitoring of metabolic dysfunction-associated steatotic liver disease. The review also highlights the evolving role of steatosis quantification as a treatment response marker and future directions in precision hepatology.
Citation	Moriyama K. Evaluation methods of hepatic steatosis: From conventional techniques to emerging biomarkers. World J Hepatol 2025; In press

Received	2025-08-07 01:54
Peer-Review Started	2025-08-07 01:54
First Decision by Editorial Office Director	2025-08-27 08:22
Return for Revision	2025-08-27 08:22
Revised	2025-09-18 09:46
Publication Fee Transferred
Second Decision by Editor	2025-12-01 03:10
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-02 03:40
Articles in Press	2025-12-02 03:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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