Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	112843
Country	United Arab Emirates

Category	Allergy
Manuscript Type	Minireviews
Article Title	Food protein-induced enterocolitis syndrome in children: An updated review on pathogenesis, diagnosis, and management
Manuscript Source	Invited Manuscript
All Author List	Khadija Alshehhi, Rahaf Abughosh, Gawahir Abdelrahman, Abdalqader Abujouda, Ahmed Elghoudi and Rana Bitar
Funding Agency and Grant Number
Corresponding Author	Rana Bitar, Assistant Professor, Division of Pediatric Gastroenterology, Sheikh Khalifa Medical City, Al Karamah Street, Abu Dhabi 51900, United Arab Emirates. rahmad@seha.ae
Key Words	Food allergy; Allergy; Children; Enterocolitis; Protein induced enterocolitis
Core Tip	Food Protein Induced Enterocolitis Syndrome is a non-IgE-mediated hypersensitivity that affects the gastrointestinal tract following ingestion of trigger food. It typically presents in infancy, and is characterised by repetitive, protracted vomiting that begins approximately 1 to 4 hours after ingestion of specific foods. The pathophysiology involves predominantly cell-mediated immune mechanisms. Patients are often misdiagnosed to have sepsis, viral gastroenteritis, or a surgical abdomen. Management includes both acute care during the episodes and long-term dietary modifications and nutritional support. Most children recover from the disease. Multicentre randomised control trials are required to build evidence-based guidelines for the diagnosis, acute treatment, and oral immunotherapy. Additionally, awareness of FPIES remains limited among paediatricians and emergency care providers. More work needs to be targeted at increasing the awareness amongst first line care professionals
Citation	Alshehhi K, Abughosh R, Abdelrahman G, Abujouda A, Elghoudi A, Bitar R. Food protein-induced enterocolitis syndrome in children: An updated review on pathogenesis, diagnosis, and management. World J Clin Pediatr 2026; In press

Received	2025-08-07 01:55
Peer-Review Started	2025-08-07 01:56
First Decision by Editorial Office Director	2025-09-04 07:47
Return for Revision	2025-09-04 07:47
Revised	2025-09-17 17:02
Publication Fee Transferred
Second Decision by Editor	2026-01-14 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-14 08:13
Articles in Press	2026-01-14 08:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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