| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Case Control Study |
| Article Title |
Immunogenetic and molecular biomarkers in COVID-19 and hepatitis C virus infection: Evaluating HLA (rs1131500), IGF-2 and I-FABP for diagnostic potential
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Amal Ahmed Mohamed, Rasha M Ahmed Abdel-Hamid, Amr Amin, Eman Al Hussain A Gawad, Salma Mohamed Saed, Dalia A Gaber, Mohamed Ahmed Ezz Al Arab, Waleed El-Agawy, Mohammed Zakaria Ali AbuRahma, Heba Ahmed Elosaily, Elsaeed E Shaaban, Shaymaa A Ismail and Amany A Sakr |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Amany A Sakr, PhD, Department of Biotechnology, BENI-SUEF UNIVERSITY, Department of Biotechnology, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Egypt. Electronic address: amanyawad29_sd@psas.bsu.edu.eg, Beni-Suef 62521, Egypt. amanyawad29_sd@psas.bsu.edu.eg |
| Key Words |
COVID-19; Hepatitis C virus; Immunogenetics; Human leukocyte antigen (rs1131500); Insulin-like growth factor-2; Intestinal fatty acid binding protein; Biomarkers |
| Core Tip |
This study identifies insulin-like growth factor 2 as a robust molecular biomarker for distinguishing between coronavirus disease 2019 (COVID-19), hepatitis C virus, and co-infection, with the highest diagnostic performance in co-infected individuals. Intestinal fatty acid binding protein showed selective utility in co-infections, while interferon-gamma displayed a protective association. Genotyping of human leukocyte antigen rs1131500 revealed the TT genotype as more frequent in COVID-19 and co-infection cases, suggesting a potential immunogenetic risk factor. These findings provide new insight into host immune responses and offer clinically relevant biomarkers for diagnosis and personalized management of viral infections. |
| Citation |
Mohamed AA, Abdel-Hamid RM, Amin A, Gawad EAHA, Saed SM, Gaber DA, Ezz Al Arab MA, El-Agawy W, AbuRahma MZA, Elosaily HH, Shaaban EE, Ismail SA, Sakr AA. Immunogenetic and molecular biomarkers in COVID-19 and hepatitis C virus infection: Evaluating HLA (rs1131500), IGF-2 and I-FABP for diagnostic potential. World J Hepatol 2025; In press |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
