Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	112853
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Long-term survival after treatment of gastric cancer with S-1 plus oxaliplatin regimen and sintilimab: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Jun Pan, Ping Li, Yu-He Zhou, Ting-Ting Pan, Yi-Tian Chen and Xiao-Yuan Chu
Funding Agency and Grant Number
Corresponding Author	Xiao-Yuan Chu, MD, Department of Oncology, Jinling Hospital, Medical School of Nanjing University, No. 305 Zhongshan East Road, Nanjing 210002, Jiangsu Province, China. chuxiaoyuan0@163.com
Key Words	Metastatic gastric cancer; Sintilimab; Immunotherapy; Chemotherapy; Progression-free survival; Case report
Core Tip	Chemotherapy combined with immunotherapy is the standard first-line treatment for metastatic gastric cancer. However, the first-line median progression-free survival is only about 7 months. This article reports a case of metastatic gastric cancer in which the patient received S-1 plus oxaliplatin regimen with sintilimab, followed by maintenance therapy with S-1 and sintilimab. The patient achieved a partial response and a progression-free survival of 23 months. Moreover, the treatment was temporarily paused for 6 months due to pneumonia. However, upon re-evaluation 6 months later, the tumor continued to regress. This combination therapy has shown encouraging results and warrants further study.
Citation	Pan J, Li P, Zhou YH, Pan TT, Chen YT, Chu XY. Long-term survival after treatment of gastric cancer with S-1 plus oxaliplatin regimen and sintilimab: A case report. World J Gastrointest Oncol 2025; In press

Received	2025-08-08 05:59
Peer-Review Started	2025-08-08 05:59
To Make the First Decision
Return for Revision	2025-08-22 08:34
Revised	2025-09-05 02:27
Second Decision	2025-10-20 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 07:10
Articles in Press	2025-10-20 07:10
Publication Fee Transferred	2025-09-08 06:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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