Publication Name	World Journal of Clinical Cases
Manuscript ID	112880
Country	China

Category	Hematology
Manuscript Type	Case Report
Article Title	Key role of Levitt’s carbon monoxide breath test in revealing coexistent Gilbert syndrome and erythropoietic protoporphyria: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Ling-Ling Kang and Hou-De Zhang
Funding Agency and Grant Number
Corresponding Author	Hou-De Zhang, PhD, Department of Gastroenterology, Nanshan Hospital, Guangdong Medical University, No. 89 Taoyuan Road, Nanshan District, Shenzhen 518052, Guangdong Province, China. szkjk@126.com
Key Words	Isolated hyperbilirubinemia; Erythropoietic protoporphyria; Gilbert syndrome; Hemolysis; Levitt’s carbon monoxide breath test; Erythrocyte lifespan; Case report
Core Tip	This first-reported case of coexisting Gilbert syndrome and erythropoietic protoporphyria highlights Levitt’s carbon monoxide breath test as a pivotal non-invasive tool for diagnosing rare and complex causes of hyperbilirubinemia. The test confirmed severely shortened red blood cell lifespan (11 days), resolving diagnostic uncertainty after conventional tests failed, and guided definitive genetic diagnosis of dual uridine diphosphate glucuronosyl transferase 1A1 and ferrochelatase mutations.
Citation	Kang LL, Zhang HD. Key role of Levitt’s carbon monoxide breath test in revealing coexistent Gilbert syndrome and erythropoietic protoporphyria: A case report. World J Clin Cases 2025; In press

Received	2025-08-08 06:03
Peer-Review Started	2025-08-08 06:03
First Decision by Editorial Office Director	2025-09-17 08:20
Return for Revision	2025-09-17 08:20
Revised	2025-09-30 13:18
Publication Fee Transferred
Second Decision by Editor	2025-12-18 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-18 06:58
Articles in Press	2025-12-18 06:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com