Publication Name	World Journal of Hepatology
Manuscript ID	112934
Country	Czech Republic

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Patients with primary sclerosing cholangitis with and without end-stage liver disease have similar outcomes after liver transplantation
Manuscript Source	Invited Manuscript
All Author List	Mojmir Hlavaty, Jan Brezina, Pavel Wohl, Istvan Modos, Lukas Bajer, Ondrej Fabian, Andrea Vajsova, Tomas Hucl and Pavel Drastich
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Health of the Czech Republic in cooperation with the Czech Health Research Council No. NU21J-06-00027 and No. NU22-06-00269 Ministry of Health, Czech Republic (Institute for Clinical and Experimental Medicine) No. IN 00023001
Corresponding Author	Pavel Drastich, Associate Professor, MD, PhD, Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic. padr@ikem.cz
Key Words	Primary sclerosing cholangitis; Liver transplant; Recurrence of primary sclerosing cholangitis; Cytomegalovirus; Acute cellular rejection; Overlap syndrome; Graft failure
Core Tip	This study demonstrated the outcomes of liver transplantation (LT) recipients with primary sclerosing cholangitis (PSC) and risk factors for recurrence of PSC (rPSC) and graft failure. Patients with PSC undergoing LT for end-stage liver disease have similar rPSC rates, graft failure rates, and overall survival comparable to those undergoing LT for non-end-stage liver disease indications (e.g., recurrent bacterial cholangitis). Acute cellular rejection, cytomegalovirus infection, and longer postoperative hospitalization were associated with both rPSC and graft failure. Identification of risk factors is necessary to better understand the pathogenesis of rPSC.
Citation	Hlavaty M, Brezina J, Wohl P, Modos I, Bajer L, Fabian O, Vajsova A, Hucl T, Drastich P. Patients with primary sclerosing cholangitis with and without end-stage liver disease have similar outcomes after liver transplantation. World J Hepatol 2026; In press

Received	2025-08-11 15:19
Peer-Review Started	2025-08-11 15:19
First Decision by Editorial Office Director	2025-08-27 08:24
Return for Revision	2025-08-27 08:24
Revised	2025-09-25 02:15
Publication Fee Transferred
Second Decision by Editor	2026-01-08 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-08 05:54
Articles in Press	2026-01-08 05:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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