| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
GATA2 deficiency exacerbates chronic liver injury via disrupting hepatocyte death-regeneration balance: Clinical, histopathological, and molecular evidence
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yun-Fen Chen, Su-Qun Li, Jing Zhang, Wen-Ting Ma, Ying Zhou, Jian-Xu Rao, Yu Yi, Qi-Jiao Cheng, Wei-Wei Zhong, Huan Chen, Ying-Hua Chen, Ya-Wen Luo and Yi-Huai He |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Planning Projects of Guizhou Province |
QKHJC-MS(2025)384 |
| Health Research Project of Guizhou Province |
gzwkj2023121 |
| Science and Technology Research Foundation of Zunyi City |
ZSKHHZ(2023)470 |
| WBE Liver Fibrosis Foundation |
CFHPC2025028 |
| Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund |
iGandanF-1082024-RGG018 |
|
| Corresponding Author |
Yi-Huai He, MD, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi 563000, Guizhou Province, China. 993565989@qq.com |
| Key Words |
GATA2 deficiency; Aplastic anemia; Chronic liver injury; Hepatocyte death-regeneration balance; Unfolded protein response; Antioxidant response |
| Core Tip |
GATA-binding protein 2 (GATA2) is known to play a crucial role in maintaining the stemness of hematopoietic stem cells, but its involvement in chronic liver injury (CLI), such as cirrhosis, remains unclear. Through an investigation into clinical cases and experimental models, this study demonstrates that GATA2 deficiency drives the progression of CLI by disrupting the hepatocyte death-regeneration balance. The findings suggest that GATA2 mutations contribute not only to aplastic anemia pathogenesis but also act as a causative factor in CLI, highlighting its potential as a therapeutic target for managing liver complications in aplastic anemia patients. |
| Citation |
Chen YF, Li SQ, Zhang J, Ma WT, Zhou Y, Rao JX, Yi Y, Cheng QJ, Zhong WW, Chen H, Chen YH, Luo YW, He YH. GATA2 deficiency exacerbates chronic liver injury via disrupting hepatocyte death-regeneration balance: Clinical, histopathological, and molecular evidence. World J Stem Cells 2025; In press |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
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|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
