Publication Name	World Journal of Diabetes
Manuscript ID	112942
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Yuan Chen, Zhe Ji, Kang Guo, Hao-Nan Wang, Chen-Chen Zhu, Tao Li, Xiang-Bin Zhao, Yu-Ting Wang, Qiang Li, Pei-Sheng Jin and Xue-Yang Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82172224 Xuzhou Health Commission Science and Technology Project No. XWKYHT20220136 Xuzhou Health Commission Youth Project No. XWKYHT20220145
Corresponding Author	Xue-Yang Li, Associate Professor, Department of Plastic Surgery, Affiliated Hospital of Xuzhou Medical University, Huai-hai West Road, Xuzhou 221006, Jiangsu Province, China. lmlxy240923@163.com
Key Words	Fractional carbon dioxide; Photothermal effect; Mesenchymal stem cells; Exosomes; Sphingosine-1-phosphate; Diabetic wound
Core Tip	In this study, adipose-derived mesenchymal stem cells were preconditioned with low-energy fractional carbon dioxide laser irradiation, utilizing a controlled photothermal effect to enhance the bioactivity of their secreted exosomes. These exosomes exhibited elevated levels of sphingosine-1-phosphate and significantly promoted endothelial cell proliferation, migration, and tube formation through activation of the sphingosine-1-phosphate receptor 1 protein kinase B/hypoxia-inducible factor 1 alpha signaling pathway, ultimately accelerating diabetic wound healing in vivo.
Citation	Chen JY, Ji Z, Guo K, Wang HN, Zhu CC, Li T, Zhao XB, Wang YT, Li Q, Jin PS, Li XY. Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis. World J Diabetes 2025; In press

Received	2025-08-11 05:48
Peer-Review Started	2025-08-15 00:17
To Make the First Decision
Return for Revision	2025-09-16 09:44
Revised	2025-09-29 18:34
Second Decision	2025-11-06 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-13 06:50
Articles in Press	2025-11-13 06:50
Publication Fee Transferred	2025-09-30 14:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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