Publication Name	World Journal of Cardiology
Manuscript ID	112956
Country	United States

Category	Medicine, General & Internal
Manuscript Type	Meta-Analysis
Article Title	Comparative efficacy and safety of chlorthalidone vs hydrochlorothiazide in hypertension management: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Usha Kumari, Manaswini Kaka, Fakhar Abbas, Amar Rai, Sanjana Kumari, Hakim Ullah Wazir and Salim Surani
Funding Agency and Grant Number
Corresponding Author	Salim Surani, Department of Medicine and Pharmacology, Texas A and M University, 40 Bizzell Street, College Station, TX 77843, United States. srsurani@hotmail.com
Key Words	Hypertension; Chlorthalidone; Hydrochlorothiazide; Blood pressure reduction; Cardiovascular outcomes
Core Tip	Hypertension is a leading cause of cardiovascular disease, chlorthalidone and hydrochlorothiazide are widely used treatments. This meta-analysis compared their efficacy and safety in adults with primary hypertension, including 11 studies published from 2005 to 2025. Chlorthalidone achieved greater reductions in both systolic blood pressure and diastolic blood pressure, as well as superior nocturnal control (P = 0.0002). Cardiovascular safety was similar, with a nonsignificant reduction in myocardial infarction risk for chlorthalidone and no difference in stroke or mortality, but hydrochlorothiazide had a lower risk of hypokalemia. The findings highlight that drug choice should be tailored to individual patient needs, balancing stronger blood pressure reduction from chlorthalidone against the lower hypokalemia risk of hydrochlorothiazide.
Citation	Kumari U, Kaka M, Abbas F, Rai A, Kumari S, Wazir HU, Surani S. Comparative efficacy and safety of chlorthalidone vs hydrochlorothiazide in hypertension management: A systematic review and meta-analysis. World J Cardiol 2025; In press

Received	2025-08-11 01:32
Peer-Review Started	2025-08-11 01:33
First Decision by Editorial Office Director	2025-09-03 03:42
Return for Revision	2025-09-03 03:42
Revised	2025-10-01 01:52
Publication Fee Transferred
Second Decision by Editor	2025-12-17 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-17 09:36
Articles in Press	2025-12-17 09:36
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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