Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	112961
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Gut microbiota as a potential predictor of therapeutic response in adults with Crohn’s disease: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Amit Kumar Dutta, Subitha Vishruth, Sai Lakshmi Kovi, Piyush Dadhich, Jagadish Polavarapu and Dilip Abraham
Funding Agency and Grant Number
Corresponding Author	Amit Kumar Dutta, FRCPE, Professor, Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Ground Floor, Williams Building, Vellore 632004, Tamil Nadu, India. akdutta1995@yahoo.co.in
Key Words	Gut microbiota; Crohn’s disease; Therapy; Predictor; Diversity; Bacteria
Core Tip	Crohn’s disease is a chronic inflammatory bowel condition requiring lifelong therapy. However, about one-third of patients do not respond to any particular treatment, and a change of therapy is needed. There is a need for identifying predictors of therapy before treatment to avoid non-response, but such markers are uncommon. Accumulating evidence suggests that the gut bacterial population can serve as a potentially useful prediction tool. In this review, we have presented the current status of the role of gut microbial community as a biomarker of response. The results are encouraging but further work is needed before they can be used in clinical practice.
Citation	Dutta AK, Vishruth S, Kovi SL, Dadhich P, Polavarapu J, Abraham D. Gut microbiota as a potential predictor of therapeutic response in adults with Crohn’s disease: A systematic review. World J Gastrointest Pathophysiol 2025; In press

Received	2025-08-11 01:36
Peer-Review Started	2025-08-11 01:36
To Make the First Decision
Return for Revision	2025-09-01 08:54
Revised	2025-09-13 19:38
Second Decision	2025-11-20 05:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-20 05:07
Articles in Press	2025-11-20 05:07
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Edit the Manuscript by Language Editor
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ISSN	2150-5330 (online)
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