Publication Name	World Journal of Gastroenterology
Manuscript ID	112972
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Study
Article Title	Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Yang Wang, Guang-Hui Ma, Ming-Yue Qu, Qi-Shui Xu and Hai-Xia Huang
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Health and Medical Center Star Talent Program 2023QMX11 Shanghai Health and Medical Center Star Talent Program 2023QMX01
Corresponding Author	Qi-Shui Xu, Department of Anesthesiology, Wuxi No. 2 Chinese Medicine Hospital, No. 390 Xincheng Road, Taihu Sub-district, Binhu District, Wuxi 214121, Jiangsu Province, China. 810204666@qq.com
Key Words	Cardiovascular risk; Framingham risk score; Metabolic dysfunction-associated steatotic liver disease; Receiver operating characteristic curve; Serum uric acid-to-high-density lipoprotein cholesterol ratio
Core Tip	This study demonstrated that an elevated uric acid-to-high-density lipoprotein cholesterol ratio (UHR) was independently associated with a higher predicted 10-year CVD risk, as estimated by the Framingham risk score, in a large cohort of Asian patients with metabolic dysfunction-associated steatotic liver disease. A distinct linear dose-response association between increasing UHR levels and CVD risk was observed. Notably, UHR exhibited superior predictive performance compared with conventional biomarkers (area under the curve = 0.655), with an optimal cutoff value of 292. Readily obtainable from routine biochemical testing, UHR thus represents a simple and cost-effective indicator for early CVD risk stratification in patients with metabolic dysfunction-associated steatotic liver disease.
Citation	Wang Y, Ma GH, Qu MY, Xu QS, Huang HX. Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; In press

Received	2025-08-12 06:05
Peer-Review Started	2025-08-12 06:06
To Make the First Decision
Return for Revision	2025-09-03 10:09
Revised	2025-09-16 06:17
Second Decision	2025-11-12 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-12 10:41
Articles in Press	2025-11-12 10:41
Publication Fee Transferred	2025-09-22 00:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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