Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	112981
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Survival prognosis in advanced HER-2 negative gastric cancer treated with immunochemotherapy: A novel model
Manuscript Source	Invited Manuscript
All Author List	Zhi-Yuan Yao, Gang Bao, Geng-Chen Li, Qiu-Lin Hao, Li-Jie Ma, Yue-Xuan Rao, Ke Xu, Xiao Ma and Zheng-Xiang Han
Funding Agency and Grant Number
Corresponding Author	Zheng-Xiang Han, PhD, Professor, Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Xuzhou 221000, Jiangsu Province, China. xzpxlgc@163.com
Key Words	Gastric cancer; Programmed death-1 inhibitor; Predictive model; Neutrophil-to-lymphocyte ratio; C-reactive protein-albumin-lymphocyte index; Efficacy
Core Tip	This study developed and validated a novel survival prediction model for advanced HER-2 negative gastric cancer patients receiving immunotherapy combined with chemotherapy. A retrospective analysis of 200 patients identified programmed death ligand 1 expression, microsatellite instability, tumor-node-metastasis stage, tumor differentiation, neutrophil-to-lymphocyte ratio, and C-reactive protein-albumin-lymphocyte index as independent prognostic factors. Based on these factors, nomogram models for progression-free survival and overall survival were constructed and validated using the concordance index (C-index) and area under the curve. The results showed good discrimination ability in both the training and validation sets, indicating that the model effectively predicts patient survival outcomes and provides strong support for personalized treatment decisions.
Citation	Yao ZY, Bao G, Li GC, Hao QL, Ma LJ, Rao YX, Xu K, Ma X, Han ZX. Survival prognosis in advanced HER-2 negative gastric cancer treated with immunochemotherapy: A novel model. World J Gastrointest Oncol 2025; In press

Received	2025-08-12 06:26
Peer-Review Started	2025-08-12 06:29
To Make the First Decision
Return for Revision	2025-08-22 08:35
Revised	2025-08-30 16:55
Second Decision	2025-10-11 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-11 05:40
Articles in Press	2025-10-11 05:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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