Publication Name	World Journal of Psychiatry
Manuscript ID	112996
Country	China

Category	Psychiatry
Manuscript Type	Observational Study
Article Title	Prevalence, severity, and risk factors for depressive and anxiety symptoms among adolescents: A cross-sectional study
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Dong Yang, Jing Zhang, Man Yang, Ling-Shu Luan, Jun-Jie Liu and Xiao-Bin Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Suzhou Clinical Medical Center for Mood Disorders No. Szlcyxzx202109 Suzhou Key Laboratory No. SZS2024016 Multicenter Clinical Research on Major Diseases in Suzhou No. DZXYJ202413 General Program of Lianyungang Health Committee No. 202336
Corresponding Author	Xiao-Bin Zhang, Professor, Department of Psychiatry, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, No. 11 Guangqian Road, Suzhou 215137, Jiangsu Province, China. zhangxiaobim@163.com
Key Words	Adolescent; Depression; Anxiety; Risk factors; Functional constipation, Patient Health Questionnaire-9; Generalized Anxiety Disorder-7
Core Tip	This large-scale cross-sectional study of 22925 Chinese adolescents reveals concerning rates of depression (16.0%) and anxiety (24.1%) symptoms, with approximately 10% reporting moderate to severe symptoms. The study uniquely identifies functional constipation as a significant risk factor for both conditions, potentially reflecting brain-gut axis dysfunction. Female sex, smoking, parental conflict, lower household income, reduced physical activity, and excessive electronic device use were also identified as risk factors, while social support emerged as protective. These findings underscore the urgent need for comprehensive screening and targeted interventions addressing modifiable risk factors to improve adolescent mental health outcomes.
Citation	Yang HD, Zhang J, Yang M, Luan LS, Liu JJ, Zhang XB. Prevalence, severity, and risk factors for depressive and anxiety symptoms among adolescents: A cross-sectional study. World J Psychiatry 2025; In press

Received	2025-08-12 06:17
Peer-Review Started	2025-08-12 06:19
To Make the First Decision
Return for Revision	2025-08-14 08:50
Revised	2025-08-20 09:18
Second Decision	2025-10-21 02:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-21 09:02
Articles in Press	2025-10-21 09:02
Publication Fee Transferred	2025-08-21 13:14
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Typeset the Manuscript

ISSN	2220-3206 (online)
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