Publication Name	World Journal of Diabetes
Manuscript ID	112999
Country	Israel

Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Study
Article Title	Glucagon-like peptide 1 receptor agonists switching patterns in type two diabetes: A retrospective real-world study
Manuscript Source	Unsolicited Manuscript
All Author List	Sameer Kassem, Buthaina Khalaila, Nili Stein and Adnan Zaina
Funding Agency and Grant Number
Corresponding Author	Sameer Kassem, Head, Department of Internal Medicine, Technion Israel Institute of Technology, Michal 7, Haifa 3436212, Israel. sameerk@technion.ac.il
Key Words	Type 2 diabetes mellitus; Glucagon-like peptide-1 receptor agonists; Glycated hemoglobin; Glycemic control; Switching; Real world
Core Tip	This retrospective study analyzed the effects of switching between glucagon-like peptide-1 receptor agonists (GLP-1RA) in patients with type 2 diabetes mellitus. It found that 25.5% of over 70000 patients changed GLP-1RA regimens, with most experiencing significant glycated hemoglobin reductions, from 8.5% to 7.6%. Notably, switching from daily to weekly GLP-1RA was associated with the highest improvement rate (81%), demonstrating that such transitions are a practical and effective alternative to treatment intensification for better glycemic control.
Citation	Kassem S, Khalaila B, Stein N, Zaina A. Glucagon-like peptide 1 receptor agonists switching patterns in type two diabetes: A retrospective real-world study. World J Diabetes 2025; In press

Received	2025-08-12 02:23
Peer-Review Started	2025-08-13 00:11
To Make the First Decision
Return for Revision	2025-09-03 03:12
Revised	2025-09-14 08:24
Second Decision	2025-10-13 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 10:31
Articles in Press	2025-10-20 10:31
Publication Fee Transferred	2025-09-15 04:50
Edit the Manuscript by Language Editor	2025-10-22 04:48
Typeset the Manuscript

ISSN	1948-9358 (online)
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