Publication Name	World Journal of Hepatology
Manuscript ID	113004
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Dynamic immune response and influencing factors in COVID-19 patients with non-alcoholic fatty liver disease: A cohort study
Manuscript Source	Invited Manuscript
All Author List	Pan Yan, Rui Li, Xiao-Yan Yuan, Yong Wang, Li-Juan Lan, Xiao-Ping Yu and Da-Feng Liu
Funding Agency and Grant Number	Funding Agency Grant Number Chengdu Science and Technology Bureau 2021-YF05-00536-SN
Corresponding Author	Da-Feng Liu, The First Ward of Internal Medicine, Public Health Clinical Center of Chengdu, No.377 Jingming Road, Jinjiang District, Chengdu 610060, Sichuan Province, China. ldf312@126.com
Key Words	COVID-19; Non-alcoholic fatty liver disease; Lymphocyte subsets; Dynamic immune response; Risk factors
Core Tip	This study reveals that coronavirus disease 2019 patients with non-alcoholic fatty liver disease (NAFLD) exhibit prolonged immune imbalance. Key risk factors - including age ≥ 60 years, significant liver fibrosis, multimorbidity (≥ 3 conditions), obesity, elevated liver enzymes, elevated low-density lipoprotein cholesterol and hemoglobin A1c - worsen immune imbalance. Notably, even lean NAFLD patients show persistent immune disturbances. These findings highlight the need for tailored clinical monitoring in coronavirus disease 2019-NAFLD patients, particularly for older adults, those with metabolic dysfunction, or advanced liver disease, to mitigate long-term immunological complications.
Citation	Yan P, Li R, Yuan XY, Wang Y, Lan LJ, Yu XP, Liu DF. Dynamic immune response and influencing factors in COVID-19 patients with non-alcoholic fatty liver disease: A cohort study. World J Hepatol 2025; In press

Received	2025-08-12 06:23
Peer-Review Started	2025-08-12 06:24
First Decision by Editorial Office Director	2025-09-17 08:25
Return for Revision	2025-09-17 08:25
Revised	2025-09-25 08:19
Publication Fee Transferred
Second Decision by Editor	2025-12-08 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-08 11:15
Articles in Press	2025-12-08 11:15
Edit the Manuscript by Language Editor	2025-12-10 02:55
Typeset the Manuscript

ISSN	1948-5182 (online)
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