Publication Name	World Journal of Gastroenterology
Manuscript ID	113010
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effects and mechanism of Bifidobacterium on intestinal inflammation resulting from deoxycholic acid-induced M1 polarization of macrophages
Manuscript Source	Unsolicited Manuscript
All Author List	Peng-Chun Yang, Chun-Yan Xiao, Jing Wang, Cai-Hua Yan, Qi-Yi Li, Shi-Yu Li, Jian Li, Li-Jing Zhang and Chi-Bing Dai
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Project of Hubei Provincial Health Commission WJ2021F060 Open Fund of the Basic and Clinical Pathology Research Center of Three Gorges University RHKFBL2022-13
Corresponding Author	Chi-Bing Dai, Department of Gastroenterology, Affiliated Renhe Hospital of China Three Gorges University, No. 435 Yiling Road, Yichang 443001, Hubei Province, China. dchibing@126.com
Key Words	High-fat diet; Bifidobacterium; Deoxycholic acid; Macrophage polarization; Microbiota; Intestinal inflammation
Core Tip	A high-fat diet increases fecal deoxycholic acid (DCA), inducing M1 macrophage polarization and intestinal inflammation. Bifidobacterium mitigates this by reducing the production of DCA, inhibiting M1 polarization, and partially restoring gut microbiota balance. Hence, they can be employed for treating high-fat diet-associated colitis. This study aims to investigate changes in intestinal flora, fecal DCA levels, and cytokine profiles.
Citation	Yang PC, Xiao CY, Wang J, Yan CH, Li QY, Li SY, Li J, Zhang LJ, Dai CB. Effects and mechanism of Bifidobacterium on intestinal inflammation resulting from deoxycholic acid-induced M1 polarization of macrophages. World J Gastroenterol 2025; In press

Received	2025-08-13 01:51
Peer-Review Started	2025-08-13 01:51
First Decision by Editorial Office Director	2025-09-08 10:12
Return for Revision	2025-09-08 10:12
Revised	2025-10-23 11:55
Publication Fee Transferred	2025-10-28 03:22
Second Decision by Editor	2025-12-11 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-11 09:22
Articles in Press	2025-12-11 09:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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