Publication Name	World Journal of Gastroenterology
Manuscript ID	113017
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Application of traditional Chinese medicine integrated therapy based on Tuina and herbal medicine in pediatric diarrhea
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Zhu, Hai-Cheng Dong, Yao Zhang, Xiao-Ai Wang, Jun-Yi Chen and Jing-Jing Wang
Funding Agency and Grant Number	Funding Agency Grant Number Key Research and Development Program of Zhejiang Province No. 2024C03211 Traditional Chinese Medicine Science and Technology Plan Project of Zhejiang Province No. 2023ZL498
Corresponding Author	Yu Zhu, Department of Traditional Chinese Medicine, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 57 Zhugan Lane, Wulin Street, Gongshu District, Hangzhou 310003, Zhejiang Province, China. 6504036@zju.edu.cn
Key Words	Pediatric; Diarrhea; Traditional Chinese medicine; Tuina; Herbal medicine
Core Tip	This review elucidates the distinct mechanisms by which integrated traditional Chinese medicine therapies Tuina massage and topical herbal medicine ameliorate pediatric diarrhea. We highlight that Tuina primarily modulates neuro-immune pathways to regulate motility and inflammation, while herbal applications directly restore intestinal barrier integrity and reprogram enterocyte metabolism. Crucially, this work synthesizes evidence for their synergistic action in repairing the gut barrier, a core pathophysiological defect, providing a mechanistic foundation for non-pharmacological, holistic complementary strategies in children.
Citation	Zhu Y, Dong HC, Zhang Y, Wang XA, Chen JY, Wang JJ. Application of traditional Chinese medicine integrated therapy based on Tuina and herbal medicine in pediatric diarrhea. World J Gastroenterol 2025; In press

Received	2025-08-19 08:35
Peer-Review Started	2025-08-19 08:35
To Make the First Decision
Return for Revision	2025-09-12 03:04
Revised	2025-09-18 08:45
Second Decision	2025-10-21 02:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-21 05:47
Articles in Press	2025-10-21 05:47
Publication Fee Transferred	2025-09-24 02:11
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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